HIV infections and AIDS development: the role of adjuvant activation

Medical Hypotheses
H C Grassi, E D Andrade

Abstract

The human immunodeficiency virus (HIV) has probably coexisted with humans for nearly a century. However, towards the end of the 1970s, it appeared as the etiologic agent of the acquired immunodeficiency syndrome (AIDS). In this paper, we propose a hypothesis for HIV infection and AIDS development, considering the role of secondary adjuvant infections. This hypothesis takes into account the natural history of the development of the AIDS epidemic from the standpoint of an emerging infection due to the increased risk caused by anthropogenic activities, and it also considers the progression of the infection to the syndrome, in terms of cellular population dynamics.

References

Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·T SeshammaR J Pomerantz
Mar 1, 1992·AIDS Research and Human Retroviruses·G MyersB Korber
Jul 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·M I BukrinskyM Stevenson
Nov 8, 1991·Science·M A Garcia-Blanco, B R Cullen
Jan 1, 1990·AIDS·M Eigen, K Nieselt-Struwe
May 1, 1986·The Journal of Clinical Investigation·D D HoM S Hirsch
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·T M FolksA S Fauci
Jul 11, 1986·Science·S GartnerM Popovic
Jan 16, 1987·Science·D FuchsH Wachter
Mar 13, 1986·Nature·A HausenH Wachter
Aug 1, 1994·Current Opinion in Immunology·G Pantaleo, A S Fauci
Jun 18, 1998·Cell·D Finzi, R F Siliciano
Jun 10, 2000·Science·B KorberT Bhattacharya

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Citations

Apr 22, 2008·Development and Psychopathology·Lia C H FernaldMegan R Gunnar

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