HIV patients have impaired diastolic function that is not aggravated by anti-retroviral treatment

Cardiovascular Drugs and Therapy
Ricardo Fontes-CarvalhoAdelino Leite-Moreira

Abstract

Recent studies have shown that HIV infection is independently associated with heart failure. Diastolic dysfunction (DD) is frequent in HIV patients, but it is unclear whether this is an effect of the HIV infection itself or of the anti-retroviral therapy (ART). Our aim was to compare diastolic function in HIV treatment-naïve, HIV-ART patients and controls. We prospectively enrolled 206 consecutive patients with HIV-1 infection and 30 controls, selected by frequency matching for age and sex. HIV patients were divided in two subgroups: ART-naïve (n = 88) and ART (n = 118). Diastolic function was assessed and graded by echocardiography, according to modern consensus criteria and using tissue Doppler analysis. Compared to controls, ART-naïve patients had lower E' velocities (E' septal: 10.2 ± 2.4 vs 11.9 ± 2.6 cm/s, p = 0.02), higher E/E' ratio (7.8 ± 1.9 vs 6.9 ± 1.6,p = 0.02) and higher prevalence of DD (19 % vs 3.3 %,p = 0.05). HIV patients under ART also had worse diastolic function compared to controls (E' septal: 10.3 ± 2.5 cm/s;p < 0.01; E/E'ratio: 8.0 ± 2.0,p < 0.01; DD prevalence: 23 %;p = 0.01), but no significant differences were found between ART-naïve and ART HIV subgroups. In multivariable logistic regression analysis...Continue Reading

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Citations

Sep 2, 2015·The American Journal of Emergency Medicine·Birdal YıldırımSelmin Dirgen Çaylak
Jul 28, 2017·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Jacqueline S da SilvaLeanne Groban
Mar 8, 2017·Current Atherosclerosis Reports·John Charles A LacsonHossein Bahrami
Jul 3, 2021·Viruses·Matthias ClaussNavneet Dhillon

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