HIV preventive vaccines. Progress to date

Drugs
J EsparzaW L Heyward

Abstract

The major conceptual problem for HIV vaccine development has been the lack of information on immune responses known to correlate with protection against HIV infection in humans. In this regard, studies on the natural history of HIV infection and AIDS, especially of people with apparent resistance to HIV infection and of patients with HIV infection who have long term survival without disease progression, may provide important information for vaccine development. In addition, a major concern for the development of broadly effective vaccines has been the extensive genetic variability which is characteristic of HIV. In spite of these unknowns, the first generation of HIV candidate vaccines has been developed and evaluated. HIV candidate vaccines based on the subunit recombinant envelope concept (gp120 or gp160) have been shown to protect chimpanzees from HIV infection on challenge, and have now been evaluated in humans in phase I and phase II trials. These products are well tolerated, and capable of inducing neutralising antibodies, but not cytotoxic T lymphocytes. A second vaccine concept, currently in phase I trials, is based on live recombinant vectors, especially using poxvirus vectors followed by boosting with subunit recombin...Continue Reading

Citations

Oct 6, 2001·Journal of Peptide Science : an Official Publication of the European Peptide Society·L J CruzO Reyes
Nov 25, 2000·International Journal of Immunopharmacology·V M PisarevJ E Talmadge
Aug 12, 1999·Biochemical and Biophysical Research Communications·A HayashiT Mayumi
May 4, 1999·Clinical and Diagnostic Laboratory Immunology·S A Schwartz, M P Nair

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