HIV-Related Lung Disorders.

Drug Discovery Today. Disease Mechanisms
H L Twigg, K S Knox

Abstract

Highly active antiretroviral therapy (HAART) has dramatically altered the spectrum of morbidity and mortality in HIV-infected patients. This has been attributed to improvements in the lung microenvironment leading to enhanced pulmonary immunity, either by preventing the progressive loss of immune function or by actually promoting immune restoration. However, these changes have been accompanied by the recognition of new pulmonary complications in HIV-infected subjects, especially those associated with immune reconstitution. In this review we will describe how HIV infection alters the normal pulmonary environment, highlight the effect of HAART on these perturbations, and discuss potential complications of HAART in the lung, focusing on the pulmonary immune reconstitution inflammatory syndrome.

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Citations

Sep 21, 2010·American Journal of Respiratory and Critical Care Medicine·Kristina CrothersAmy C Justice
May 25, 2013·Clinics in Chest Medicine·Homer L Twigg, Kenneth S Knox
Jun 28, 2016·Expert Review of Anti-infective Therapy·M B Lawani, A Morris
Feb 3, 2016·American Journal of Respiratory and Critical Care Medicine·Homer L TwiggGeorge M Weinstock
Aug 9, 2016·Translational Research : the Journal of Laboratory and Clinical Medicine·Homer L TwiggKenneth S Knox
Jan 16, 2019·PloS One·Meri R J VarkilaKerstin Klipstein-Grobusch
Dec 4, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michelle N KellyJudd E Shellito

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