PMID: 2496708Jan 1, 1989Paper

HIV replication can be blocked by recombinant human interferon beta

AIDS
B Michaelis, J A Levy

Abstract

Recombinant human interferon beta (rIFN-beta) reduces replication of HIV in cultured peripheral mononuclear cells. The effect is most pronounced when high levels of the drug are employed. Maintenance of the rIFN-beta in culture is required since removal of the agent generally leads to a return of virus production by the infected cells. Moreover, at low concentrations of the drug, a breakthrough in HIV replication is observed. High concentrations of the rIFN-beta (greater than 100 units/ml) were cytotoxic for transformed T cells. This latter observations suggests that rIFN-beta might be useful in human T-cell malignancies. Beta interferon therefore might be useful for the treatment of HIV infection, particularly since side effects of the drug are limited in treated individuals.

Citations

Jun 1, 1992·AIDS Research and Human Retroviruses·C Mackewicz, J A Levy
Aug 30, 2013·AIDS Research and Human Retroviruses·Aida SivroT Blake Ball
Dec 1, 1991·Journal of Interferon Research·P M Pitha
Feb 14, 2013·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·M Scott KillianJ Keith Killian
Jun 24, 2010·Retrovirology·Trine H MogensenSøren R Paludan
Dec 24, 2010·Journal of Virology·Jennifer LuChen Liang
Feb 1, 1990·Clinical Immunology and Immunopathology·R S KornbluthD D Richman
Nov 1, 1991·Cytokine·W L FarrarK A Clouse
Mar 1, 1994·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·A FregaA Pachì
Dec 21, 2012·Journal of Virology·Stéphanie CordeilAndrea Cimarelli
Jan 20, 2017·Journal of Virology·Suzannah J RihnSam J Wilson
Aug 21, 2012·Microbiology and Immunology·Esaki Muthu ShankarNegar Shafiei Sabet

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