HIV replication enhances production of free fatty acids, low density lipoproteins and many key proteins involved in lipid metabolism: a proteomics study.

PloS One
Suraiya RasheedArvan S Chan

Abstract

HIV-infected patients develop multiple metabolic abnormalities including insulin resistance, lipodystrophy and dyslipidemia. Although progression of these disorders has been associated with the use of various protease inhibitors and other antiretroviral drugs, HIV-infected individuals who have not received these treatments also develop lipid abnormalities albeit to a lesser extent. How HIV alters lipid metabolism in an infected cell and what molecular changes are affected through protein interaction pathways are not well-understood. Since many genetic, epigenetic, dietary and other factors influence lipid metabolism in vivo, we have chosen to study genome-wide changes in the proteomes of a human T-cell line before and after HIV infection in order to circumvent computational problems associated with multiple variables. Four separate experiments were conducted including one that compared 14 different time points over a period of >3 months. By subtractive analyses of protein profiles overtime, several hundred differentially expressed proteins were identified in HIV-infected cells by mass spectrometry and each protein was scrutinized for its biological functions by using various bioinformatics programs. Herein, we report 18 HIV-mod...Continue Reading

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Methods Mentioned

BETA
electrophoresis
protein folding
lipidation
affinity purification

Software Mentioned

Ingenuity Pathway Analysis Systems
Ingenuity Pathway Analysis ( IPA ) System
Melanie
PDQuest
Ingenuity Pathway Analysis ( IPA ) Systems
PS1
Strategene Pathway Architect ( SPA )
Global Functional Analysis programs
Ingenuity
Ingenuity Systems

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