HIV Restriction Factors and Mechanisms of Evasion.

Cold Spring Harbor Perspectives in Medicine
Michael H Malim, Paul D Bieniasz

Abstract

Retroviruses have long been a fertile model for discovering host-pathogen interactions and their associated biological principles and processes. These advances have not only informed fundamental concepts of viral replication and pathogenesis but have also provided novel insights into host cell biology. This is illustrated by the recent descriptions of host-encoded restriction factors that can serve as effective inhibitors of retroviral replication. Here, we review our understanding of the three restriction factors that have been widely shown to be potent inhibitors of HIV-1: namely, APOBEC3G, TRIM5α, and tetherin. In each case, we discuss how these unrelated proteins were identified, the mechanisms by which they inhibit replication, the means used by HIV-1 to evade their action, and their potential contributions to viral pathogenesis as well as inter- and intraspecies transmission.

References

Dec 10, 1998·Nature Medicine·J H SimonM H Malim
Aug 3, 2002·Proceedings of the National Academy of Sciences of the United States of America·Simone CowanPaul D Bieniasz
Jun 18, 2003·Cell·Reuben S HarrisMichael H Malim
Jun 26, 2003·Trends in Microbiology·Paul D Bieniasz
Oct 7, 2003·Nature Medicine·Mariana MarinDavid Kabat
Dec 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·Vasundhara VarthakaviPaul Spearman
Apr 21, 2004·Nature Structural & Molecular Biology·Qin YuNathaniel R Landau
Jul 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Theodora HatziioannouPaul D Bieniasz
Jul 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Zuzana KeckesovaGreg J Towers
Jul 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Melvyn W YapJonathan P Stoye
Jul 29, 2004·Proceedings of the National Academy of Sciences of the United States of America·Michel J PerronJoseph Sodroski
Oct 14, 2004·Journal of Virology·Nathan C GaddisMichael H Malim
Jan 15, 2005·Current Biology : CB·Melvyn W YapJonathan P Stoye
Feb 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Sara L SawyerHarmit S Malik
Jul 5, 2005·Journal of Virology·David Perez-CaballeroPaul D Bieniasz
Sep 22, 2005·Nature Reviews. Microbiology·Sébastien NisoleAli Saïb
Oct 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Lionel BerthouxJeremy Luban
Mar 17, 2006·Proceedings of the National Academy of Sciences of the United States of America·Matthew StremlauJoseph Sodroski
Apr 20, 2006·Nature Structural & Molecular Biology·Linda ChelicoMyron F Goodman
May 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·Xiaolu WuThomas J Hope
Oct 7, 2006·Science·Theodora HatziioannouPaul D Bieniasz
Oct 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ya-Lin ChiuWarner C Greene
Dec 15, 2006·Journal of Virology·Sarah Gallois-MontbrunMichael H Malim
Jan 18, 2008·Nature·Stuart J D NeilPaul D Bieniasz
Feb 15, 2008·Journal of Virology·Marc-André Langlois, Michael S Neuberger
Feb 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Greg BrennanShiu-Lok Hu
Feb 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Cesar A VirgenTheodora Hatziioannou
Feb 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Sam J WilsonGreg J Towers

❮ Previous
Next ❯

Citations

Oct 16, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Lena Al-Harthi
Dec 18, 2012·Current HIV/AIDS Reports·Anupriya AggarwalStuart G Turville
Apr 23, 2013·Cell Reports·Alexandra CribierMonsef Benkirane
Jun 5, 2013·Cell Research·Xiaoyu PanOliver T Fackler
Sep 21, 2013·Nature·Caroline GoujonMichael H Malim
Dec 15, 2012·Nature Reviews. Immunology·Michael S Diamond, Michael Farzan
May 23, 2013·International Journal for Quality in Health Care : Journal of the International Society for Quality in Health Care·Kristina Talbert-SlagleElizabeth H Bradley
Aug 14, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Alex A ComptonMichael Emerman
Aug 14, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Melvyn W Yap, Jonathan P Stoye
Jul 5, 2012·Cold Spring Harbor Perspectives in Medicine·Wesley I Sundquist, Hans-Georg Kräusslich
Apr 5, 2012·Cold Spring Harbor Perspectives in Medicine·Eric J Arts, Daria J Hazuda
Jun 8, 2012·Cold Spring Harbor Perspectives in Medicine·Jeffrey D Lifson, Nancy L Haigwood
Sep 27, 2013·Journal of Virology·Caroline BlondeauGreg J Towers
Dec 21, 2012·Journal of Virology·Stéphanie CordeilAndrea Cimarelli
Jan 18, 2013·Journal of Virology·Julia BitzegeioTheodora Hatziioannou
Jan 11, 2013·Clinical & Developmental Immunology·Johanne PoudrierMichel Roger
Oct 26, 2013·Retrovirology·Veronika LodermeyerChristine Goffinet
Nov 28, 2012·AIDS Research and Therapy·Torsak BunupuradahUNKNOWN PREDICT Study Team
Jun 1, 2013·PLoS Biology·Ann DemoginesSara L Sawyer
Mar 19, 2013·PLoS Pathogens·Sebla B KutluayPaul D Bieniasz
Aug 31, 2013·PLoS Pathogens·Fan WuVanessa M Hirsch
Dec 4, 2012·Viruses·Shuzo Urata, Jiro Yasuda
Aug 7, 2013·Viruses·Ramsés ReinaBeatriz Amorena
Sep 28, 2013·Viruses·Axel Rethwilm, Jochen Bodem
Jan 10, 2014·Nature·Michael H Malim
Jan 11, 2014·Future Virology·Sona Budhiraja, Andrew P Rice
May 14, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A Saez-CirionM Müller-Trutwin
Apr 2, 2014·Médecine sciences : M/S·Caroline Goujon
Aug 20, 2014·Proceedings of the National Academy of Sciences of the United States of America·Minghua LiShan-Lu Liu
May 24, 2014·Cellular and Molecular Life Sciences : CMLS·Jan Rehwinkel
Apr 15, 2014·Virology·Nicholas R MeyersonSara L Sawyer
Nov 22, 2014·The Journal of Infectious Diseases·Suryaram GummuluruHisashi Akiyama
Nov 13, 2014·Current Opinion in HIV and AIDS·Francesco R Simonetti, Mary F Kearney
Dec 20, 2013·Viruses·Michael S Bennett, Ramesh Akkina
Feb 23, 2013·Expert Review of Anti-infective Therapy·Richard D Sloan, Mark A Wainberg
Oct 15, 2014·Biomolecules·Cathal MahonElah Pick

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Opinion in Virology
Theodora Hatziioannou, Paul D Bieniasz
The Journal of Biological Chemistry
Reuben S HarrisDavid T Evans
© 2021 Meta ULC. All rights reserved