HIV Tat/P-TEFb Interaction: A Potential Target for Novel Anti-HIV Therapies

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Kaori AsamitsuTakashi Okamoto

Abstract

Transcription is a crucial step in the life cycle of the human immunodeficiency virus type 1 (HIV 1) and is primarily involved in the maintenance of viral latency. Both viral and cellular transcription factors, including transcriptional activators, suppressor proteins and epigenetic factors, are involved in HIV transcription from the proviral DNA integrated within the host cell genome. Among them, the virus-encoded transcriptional activator Tat is the master regulator of HIV transcription. Interestingly, unlike other known transcriptional activators, Tat primarily activates transcriptional elongation and initiation by interacting with the cellular positive transcriptional elongation factor b (P-TEFb). In this review, we describe the molecular mechanism underlying how Tat activates viral transcription through interaction with P-TEFb. We propose a novel therapeutic strategy against HIV replication through blocking Tat action.

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Citations

May 6, 2020·Viruses·Rayhane NchiouaFrank Kirchhoff
Feb 21, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Koh Fujinaga
Mar 27, 2020·Frontiers in Cell and Developmental Biology·Madalina Gabriela BarbuSilviu Cristian Voinea
Mar 12, 2020·Frontiers in Cellular and Infection Microbiology·David Ajasin, Eliseo A Eugenin
Nov 14, 2020·Viruses·Koh Fujinaga, Daniele C Cary

Methods Mentioned

BETA
immunoprecipitation
surface plasmon resonance
fluorescence complementation
FRET

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