HIV transmission between spouses living in Lu'an city, Anhui province, China: a longitudinal study

Epidemiology and Infection
Gongyan MaTai Ma

Abstract

This study aims to investigate the human immunodeficiency virus (HIV) transmission rate in HIV serodiscordant couples, in addition to the relevant influencing factors. From January 1999 to August 2016, patients with HIV/AIDS (index cases) along with their fixed partners were registered and monitored to determine the rate of HIV transmission between couples, as well as relevant influencing factors. A total of 231 HIV-positive couples were investigated, of these, 45-negative (19.48%) partners were infected with HIV via sexual transmission prior to diagnosis of the first case detected in couples. After diagnosis, the transmission rate between spouses was 0.39 per 100 person-years (2/507.7), and the cumulative transmission rate was 1.08% (2/186), which was significantly lower than the transmission rate before diagnosis (χ2 = 35.714, P < 0.001). Among the 119 HIV/AIDS patients who received antiretroviral therapy (ART), the transmission rate was 0 (0/119), whereas the transmission rate was 2.99% (2/67) in HIV/AIDS patients who did not receive ART. In addition, HIV transmission rate in serodiscordant couples was high prior to diagnosis of the index case. However, following diagnosis, the transmission rate was reduced, and the risk ...Continue Reading

References

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Jun 6, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Stéphane HugonnetRichard Hayes
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Dec 4, 2009·Sexually Transmitted Diseases·Victoria HernandoJesús Castilla
Jul 20, 2011·The New England Journal of Medicine·Myron S CohenUNKNOWN HPTN 052 Study Team
Jan 10, 2013·PloS One·Abigail M HatcherSheri D Weiser
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Jul 13, 2016·JAMA : the Journal of the American Medical Association·Alison J RodgerUNKNOWN PARTNER Study Group

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

Epidata
SPSS

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