PMID: 22358417Feb 24, 2012Paper

HIV transmitted drug resistance in adult and pediatric populations in Panama

Revista Panamericana De Salud Pública = Pan American Journal of Public Health
Juan CastilloJuan M Pascale

Abstract

To investigate the prevalence of transmitted drug-resistant HIV among adults in Panama by using a modified World Health Organization Threshold Survey (WHO-TS) and to investigate rates of initial resistance among HIV-positive infants in Panama. At the Gorgas Memorial Institute, 47 HIV-positive adults were genotyped for mutations associated with transmitted drug resistance (TDR) in the reverse transcriptase and protease genes of HIV-1, according to WHO-TS guidelines, modified to include patients ≤ 26 years old. Prevalence rates for drug-resistance mutations against three classes of antiretroviral drugs-nucleoside analog reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), and protease inhibitors-were calculated as low (< 5.0%), moderate (5.0%-15.0%), and high (> 15.0%). Twenty-five infant patients were also geno-typed and prevalence rates for drug-resistance mutations were calculated. TDR among Panamanian adults was moderate: 6 of 47 HIV-positive adults showed one or more mutations associated with TDR. Horizontal TDR mutations were moderate for NRTIs and NNRTIs and low for protease inhibitors. Vertical transmission of HIV in Panama has decreased for 2002-2007, but vertical HIV TDR pr...Continue Reading

Citations

May 3, 2014·The Journal of Antimicrobial Chemotherapy·Patricia Rojas Sánchez, Africa Holguín
Jun 21, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Á HolguínG Escobar
Jun 4, 2020·International Journal of STD & AIDS·Maria A RoblesAlexander A Martínez
Apr 3, 2019·AIDS Research and Treatment·C K ChauhanR Kumar

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