HIV type 1 infection is a risk factor for mortality in hospitalized Zambian children with measles

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
William J MossFelicity T Cutts

Abstract

Measles remains a significant cause of vaccine-preventable mortality in sub-Saharan Africa, yet few studies have investigated risk factors for measles mortality in regions of high human immunodeficiency virus type 1 (HIV-1) prevalence. Between January 1998 and July 2003, children with clinically diagnosed measles who were hospitalized at the University Teaching Hospital in Lusaka, Zambia, were enrolled in an observational study. Demographic and clinical information was recorded at enrollment and at discharge or death. Measles was confirmed by detection of antimeasles virus immunoglobulin M antibodies, and HIV-1 infection was confirmed by detection of HIV-1 RNA. Of 1474 enrolled children, 1227 (83%) had confirmed measles and known HIV-1 infection status. Almost one-third of the HIV-1-infected children with measles were <9 months of age, the age of routine measles vaccination, compared with one-fourth of the uninfected children (P = .07). Death occurred during hospitalization in 23 (12.2%) of the HIV-1-infected children and 45 (4.3%) of the HIV-1-uninfected children (p < .001) with measles. After adjusting for age, sex, and measles vaccination status, HIV-1 infection (odds ratio, 2.5; 95% confidence interval, 1.4-4.6), < or =8 ye...Continue Reading

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Citations

Jun 17, 2011·The Journal of Infectious Diseases·Raymond SandersDavid Featherstone
Jun 14, 2012·The Journal of Infectious Diseases·Mark J AbzugUNKNOWN International Maternal Pediatric Adolescent AIDS Clinical Trials Group P1024 and P1061s Protocol Teams
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