PMID: 9546802Apr 18, 1998Paper

HIV type 1 infection of human macrophages induces an upregulation of manganese superoxide dismutase gene that may protect cells from death

AIDS Research and Human Retroviruses
H RaoulD Dormont

Abstract

It has been previously demonstrated that HIV-1 infection induces a downregulation of MnSOD transcription in CD4+ lymphocytes. Using clinical isolates of macrophage-tropic HIV-1 strains we report here that conversely, purified normal human monocyte-derived macrophages (MDMs) overexpress the manganese superoxide dismutase (MnSOD) gene in response to infection and viral replication. This upregulation of MnSOD gene expression is concomitant with tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6) production and treatment of HIV-1-infected MDMs with a specific transcriptional inhibitor of TNF-alpha synthesis counteracts the HIV-1-induced MnSOD gene activation. Moreover, TNF-alpha but not IL-6 addition mimicks the effects of HIV-1 infection on MnSOD gene regulation in normal MDM cultures. These observations strongly suggest that the MnSOD gene induction detected in HIV-1-infected MDMs is triggered by TNF-alpha produced in culture supernatants in parallel to HIV-1 particle release. In contrast to MnSOD, HIV-1 infection or replication in human MDMs has no effect on copper-zinc superoxide dismutase (Cu/ZnSOD) gene expression.

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Citations

May 27, 2003·Journal of Medical Virology·Michael WangRobert S Fujinami
Aug 23, 2011·Free Radical Biology & Medicine·Adela Cota-GomezSonia C Flores
Apr 25, 2020·Viruses·Nabab KhanJonathan D Geiger

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