PMID: 9430252Jan 16, 1998Paper

HIV type 1 V3 variation dynamics in vivo: long-term persistence of non-syncytium-inducing genotypes and transient presence of syncytium-inducing genotypes during the course of progressive AIDS

AIDS Research and Human Retroviruses
S IdaS Oka

Abstract

We performed a population-based sequence analysis of the envelope V3 region of human immunodeficiency virus type 1 (HIV-1) in two infected hemophiliacs. The study was conducted over 6-9 years, extending from the asymptomatic phase to AIDS. In both patients, serial analysis showed that the V3 population at the initial stage consisted exclusively of putative non-syncytium-inducing (NSI) genotypes. Several of these clones continued to be present without change for many years until the terminal stage and often represented the dominant species in the population at each time interval. On the other hand, syncytium-inducing (SI) genotypes were initially absent but appeared shortly before severe depletion of CD4+ T cells and their proportion in the population appeared to correlate with the viral load. In sharp contrast to NSI genotypes, SI genotypes displayed a significantly shorter presence. Thus, rapid gross population changes were found in SI genotypes, which were particularly frequent in the asymptomatic phase and less frequent in the terminal stage. Furthermore, the ratio of nonsynonymous nucleotide substitutions per synonymous substitutions in the V3 region in SI genotypes was higher than the corresponding value of NSI genotypes a...Continue Reading

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Citations

Sep 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·A KinterA S Fauci
Feb 10, 2011·Journal of Translational Medicine·Hanneke SchuitemakerPaolo Lusso
Dec 29, 2010·PLoS Pathogens·Marcel E CurlinJames I Mullins
Mar 25, 2006·Uirusu·Hironori Sato, Masaru Yokoyama
Jan 27, 2006·The EMBO Journal·Paolo Lusso
Oct 29, 2010·Journal of Medical Virology·Conor J MeehanSimon A A Travers
Aug 1, 2000·Virology·P Lusso
Aug 9, 2012·Current Opinion in HIV and AIDS·Chris VerhofstedeLinos Vandekerckhove

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