HIV Viral Rebound Due to a Possible Drug-Drug Interaction between Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide and Calcium-Containing Products: Report of 2 Cases.

Journal of the International Association of Providers of AIDS Care
S Lena Kang-BirkenJohn Prichard

Abstract

Elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide (E/C/F/TAF) is a potent fixed-dose, once-daily regimen for HIV-1 treatment and has rare emergence of drug resistance. We report a potential drug-drug interaction in 2 female patients both receiving treatment for HIV and cerebral toxoplasmosis: one case between E/C/F/TAF with calcium carbonate and a second case involving leucovorin as calcium salt. Both cases resulted in rise in HIV RNA levels and emergence of M184 V mutation and resistance to elvitegravir and raltegravir. To the best of our knowledge, these 2 cases are the first reports of rapid emergence of mutation from coadministration of E/C/F/TAF and calcium.

References

Oct 6, 2010·Antimicrobial Agents and Chemotherapy·Jennifer J KiserRichard Brundage
Feb 26, 2011·Clinical Pharmacokinetics·Srinivasan RamanathanBrian P Kearney
Jun 19, 2013·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Srinivasan RamanathanBrian P Kearney
Dec 3, 2014·Journal of Clinical Pharmacology·Ivy SongStephen Piscitelli
Apr 9, 2018·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Nicolas MargotChristian Callebaut

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Citations

May 4, 2020·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C BordesP Loubet

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Methods Mentioned

BETA
biopsy

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