HIV/Hepatitis C virus-coinfected virologic responders to pegylated interferon and ribavirin therapy more frequently incur interferon-related adverse events than nonresponders do.

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Anu OsinusiShyam Kottilil

Abstract

This study aimed to assess the relationship between interferon (IFN)-related adverse effects and Hepatitis C virus (HCV) virologic response in HIV/HCV-coinfected individuals treated with pegylated interferon and ribavirin. We conducted 2 prospective, open-label trials treating HIV/HCV-coinfected individuals with pegylated interferon alpha-2b or alpha-2a and ribavirin for 48 weeks. Safety laboratories, HCV RNA, psychiatric, and ophthalmologic evaluations were performed at baseline and monthly until week 72. Responders were defined as those with HCV RNA decline of > or = 2-log drop from baseline and nonresponders were those who did not. Remarkably, of the 27 patients (50%) who developed psychiatric toxicities, 26 patients were responders, although only 1 of 14 virologic nonresponders experienced psychiatric toxicity. Other adverse effects, such as anemia and ophthalmologic toxicities, were also more frequent in responders compared with nonresponders. Decline in CD4 T-cell counts strongly correlated with HCV viral decline. Our study demonstrates coupling of antiviral effect and occurrence of adverse events in HIV/HCV-coinfected patients. These patients with IFN-related adverse effects need a multidisciplinary treatment approach, h...Continue Reading

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Citations

Jan 12, 2011·Current HIV/AIDS Reports·Eva A Operskalski, Andrea Kovacs
Jun 26, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Joseph RasimasDonald Rosenstein
May 27, 2014·AIDS Research and Human Retroviruses·Madeline OdigieShyam Kottilil
Dec 4, 2012·Expert Review of Anti-infective Therapy·Maribel Rodríguez-Torres
Nov 23, 2016·World Journal of Hepatology·Lydia Shuk Yee TangShyam Kottilil
May 15, 2020·Clinical Microbiology Reviews·Naveen KumarBarry T Rouse

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