Jun 2, 2020

Hizikia fusiforme extract enhances dendritic cell maturation in vitro and in vivo

Bioscience, Biotechnology, and Biochemistry
Mi Eun KimJun Sik Lee

Abstract

Dendritic cells (DCs) are play critical roles in the priming and regulation of immune responses. DCs rapidly process and convey these antigens to prime antigen-specific T cells. Therefore, regulation of DCs functions is important for immunity and immunotherapies. Immune adjuvants for DCs activation are needed to improve the efficacy of vaccines against tumors and many infectious diseases. Therefore, we demonstrate that H. fusiformis extract can regulate DCs maturation and activation. H. fusiformis extract induced costimulatory molecules (CD 80 and CD86), antigen-presenting molecules (major histocompatibility complex (MHC) I and II), CCR7 expression, and interleukin (IL)-12 production in DCs. These effects are associated with upregulation of mitogen-activated protein kinase (MAPK) signaling pathway. In addition, H. fusiformis extract induces costimulatory molecules on splenic DCs and activated CD8+ T cells in vivo. Taken together, these findings suggest that H. fusiformis extract may be a potential efficient immune therapeutic compound in DCs-mediated immunotherapies. Abbreviations CTL: cytotoxic T lymphocytes; DCs: dendritic cells; ERK: extracellular signal-regulated kinases; IL: interleukini; JNK: c-Jun N-terminal kinase; MAPK...Continue Reading

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Mentioned in this Paper

Interleukin-12
MAP2K1 protein, human
Regulation of Protein Kinase A Signaling Cascade
Extracellular
Regulation of Biological Process
Specific antigen
Plant Extracts
MRNA Maturation
Therapeutic agent (substance)
Immunologic Adjuvants

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