PMID: 6585136May 1, 1984Paper

HLA A, B and DR typing in idiopathic dilated cardiomyopathy: a search for immune response factors

The American Journal of Cardiology
J L AndersonE H Hammond

Abstract

Several autoimmune diseases have been associated with increased frequencies of various histocompatibility antigen (HLA) types that may be linked to immune response genes. Idiopathic dilated cardiomyopathy (IDC) has been proposed as a disease with autoimmune features, but HLA associations have not been evaluated. We performed HLA typing in 37 consecutive patients with IDC. Patients with habitual alcoholism were excluded. Results showed that no single HLA type could account for most cases; IDC is a genetically heterogeneous disease. However, uneven distributions were noted for certain types. Haplotype frequency of B27 was 0.145 in patients vs 0.033 in 5,726 local control subjects (p less than 0.001). Other A and B frequencies (except A2) were evenly distributed. HLA DR typing also revealed differences. The DR4 locus was present in 54% (19 of 35) of patients, vs 32% (26 of 82) of blood bank control subjects (p less than 0.02). The associated relative risk of DR4 was 2.2 and the etiologic fraction 0.29. Sex, disease chronicity, functional class, ejection fraction and biopsy evidence of myocarditis did not distinguish DR4-positive from DR4-negative patients, but they were older (54 +/- 12 vs 42 +/- 14 years, p less than 0.02). Of no...Continue Reading

References

Oct 7, 1976·The New England Journal of Medicine·F H Bach, J J van Rood
Oct 14, 1976·The New England Journal of Medicine·F H Bach, J J Rood
Sep 18, 1975·The New England Journal of Medicine·C Kawai, T Takatsu
Jun 1, 1979·British Heart Journal·G CambridgeC M Oakley
May 1, 1978·The American Journal of Cardiology·J W Mason
Nov 1, 1973·American Heart Journal·A B KirsnerN O Fowler
Jan 1, 1983·Immunological Reviews·A SvejgaardL P Ryder
Jan 8, 1983·British Medical Journal·G F HendriksJ J van Rood
May 1, 1980·The American Journal of Cardiology·J W MasonD R Ricci

❮ Previous
Next ❯

Citations

Jul 9, 2003·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·Q WangJ Zhang
Nov 1, 1992·Human Immunology·M MartinettiG F Bottazzo
Jun 1, 1990·Journal of the American College of Cardiology·A L CaforioW J McKenna
Dec 1, 1991·Journal of the American College of Cardiology·E B LiebermanK L Baughman
Mar 17, 1999·International Journal of Cardiology·A A HarcombeV Joysey
Nov 1, 1990·Journal of the American College of Cardiology·D A NeumannA Herskowitz
Jun 1, 1987·Journal of the American College of Cardiology·A HerskowitzK W Beisel
Apr 7, 1990·BMJ : British Medical Journal·A L CaforioW J McKenna
Nov 1, 1989·British Heart Journal·C J Limas, C Limas
Dec 1, 1994·British Heart Journal·A L Caforio
Oct 23, 2003·Proceedings of the National Academy of Sciences of the United States of America·John F ElliottKatherine M Kavanagh
Sep 21, 2013·Gene·Sabine PankuweitUNKNOWN German Competence Network of Heart Failure
Aug 27, 2010·Arthritis Care & Research·Nai Lee LuiRobert Inman
Feb 15, 1990·The American Journal of Cardiology·C J LimasM T Olivari
Oct 1, 1995·Journal of Molecular and Cellular Cardiology·H NishiA Kimura
Dec 1, 1987·The American Journal of Cardiology·W C RobertsB M McManus
Sep 20, 2016·Journal of cardiology·Tom J O'DonohoeRyan G Schrale
Mar 24, 2016·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·B JinJ Zhu
Jun 1, 1988·The American Journal of Cardiology·T R ZerbeR Duquesnoy
Sep 1, 1995·Pediatric Pathology & Laboratory Medicine : Journal of the Society for Pediatric Pathology, Affiliated with the International Paediatric Pathology Association·M M HebertB B Rogers
Jan 10, 2012·Circulation Research·Ziya KayaHugo A Katus
Dec 7, 2005·Circulation·Karen SliwaBongani M Mayosi
Apr 3, 2008·Current Opinion in Cardiology·Alida L P Caforio, Sabino Iliceto
Jun 29, 2011·Journal of Cardiovascular Medicine·Jinlong DengXiaoping Li
Oct 19, 1989·The New England Journal of Medicine·J B O'Connell
Sep 11, 2008·Autoimmunity·Alida L P CaforioSabino Iliceto
Jul 30, 1999·Biochemical and Biophysical Research Communications·S HiroiA Kimura
Jun 1, 1987·Human Pathology·C Weinstein, J J Fenoglio

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.