HLA-A*02:07 is a protective allele for EBV negative and a susceptibility allele for EBV positive classical Hodgkin lymphoma in China.

PloS One
Xin HuangAnke van den Berg

Abstract

HLA-A2 protects from EBV+ classical Hodgkin lymphoma (cHL) in Western Europe, but it is unknown whether this protective effect also exists in the Chinese population. We investigated the association of HLA-A2 and specific common and well documented HLA-A2 subtypes with EBV stratified cHL patients (n = 161) from the northern part of China. Quantitative-PCR and sequence-based subtyping was performed to identify HLA-A2 positive samples and their subtypes. 67 (42%) of the cHL patients were EBV+. There were no significant differences in percentages of HLA-A2 positivity between cHL and controls (65% vs 66%) and between EBV+ and EBV- cHL patients (70% vs 61%). The frequency distribution of HLA-A2 subtypes was significantly different between EBV stratified cHL subgroups and controls. This difference was most striking for the HLA-A*02:07 type with a frequency of 38% in EBV+ cHL, 8% in EBV- cHL and 20% in controls. Significant differences were also observed for the HLA-A*02:07, HLA-A2 (non-02:07) and the A2-negative typings between EBV+ cHL vs controls (p = 0.028), EBV- cHL vs controls (p = 0.045) and EBV+ vs EBV- cHL cases (p = 2×10(-5)). In conclusion, HLA-A*02:07 is a predisposing allele for EBV+ cHL and a protective allele for EBV- cH...Continue Reading

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Citations

Mar 21, 2013·Tissue Antigens·S J MackMarcelo Fernandez-Vina
Nov 29, 2014·Reviews in Medical Virology·Charlotte J Houldcroft, Paul Kellam
Jul 21, 2015·Tissue Antigens·K A McAulay, R F Jarrett
Feb 24, 2015·Annual Review of Immunology·Graham S TaylorAndrew D Hislop
Jul 19, 2012·PloS One·Xin HuangAnke van den Berg
Apr 14, 2018·Pathogens·Geok Wee TanArjan Diepstra
Jun 4, 2019·Journal of Internal Medicine·C ZhongS S Wang
Sep 11, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kushi KushekharArjan Diepstra
Jan 3, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Ellen E M DuckworthMichael F Criscitiello

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Methods Mentioned

BETA
PCR
biopsies

Software Mentioned

SPSS
Seqman Star
Excel®
PASW Statistics

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