HLA alleles are associated with altered risk for disease progression and central nervous system impairment of HIV-infected children

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Kumud K SinghStephen A Spector

Abstract

To examine the effects of human leukocyte antigen (HLA) alleles on HIV-1-related disease progression and central nervous system (CNS) impairment in children. Five hundred seventy-two HIV-1-infected children, identified as disease progressors or nonprogressors, were selected from PACTG P152 and P300 through a case-cohort sampling scheme. Study endpoints were HIV-1-related disease progression-free survival and time to CNS impairment. DNA was genotyped for HLA alleles using a Luminex 100 platform. Weighted Kaplan-Meier methods, and Cox proportional hazards models were used to assess the effects of HLA alleles on study endpoints. Presence of the B-27 allele (n = 20) was associated with complete protection against disease progression and CNS impairment over the median follow-up of 26 months (P < 0.0001 for both). These findings held in multivariate analyses controlling for baseline covariates including race, gender, age, log HIV-1 RNA, CD4 lymphocyte count and percent, weight for age z score and treatment, and for other genotypes shown to affect HIV-1-related disease progression. Also, although the Cw-2 allele protected against disease progression [Hazard ratio (HR), 0.48; 95% confidence interval (CI): 0.28 to 0.81; P = 0.006], the ...Continue Reading

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Citations

May 11, 2012·Retrovirology·Donato Zipeto, Alberto Beretta
Mar 18, 2016·PloS One·Kumud K SinghStephen A Spector
Jul 6, 2014·Current HIV/AIDS Reports·Asha R Kallianpur, Andrew J Levine
Nov 18, 2018·International Journal of Molecular Sciences·Ian Simon OlivierVinogran Naidoo

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