HLA alleles are associated with altered risk for disease progression and central nervous system impairment of HIV-infected children

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Kumud K SinghStephen A Spector


To examine the effects of human leukocyte antigen (HLA) alleles on HIV-1-related disease progression and central nervous system (CNS) impairment in children. Five hundred seventy-two HIV-1-infected children, identified as disease progressors or nonprogressors, were selected from PACTG P152 and P300 through a case-cohort sampling scheme. Study endpoints were HIV-1-related disease progression-free survival and time to CNS impairment. DNA was genotyped for HLA alleles using a Luminex 100 platform. Weighted Kaplan-Meier methods, and Cox proportional hazards models were used to assess the effects of HLA alleles on study endpoints. Presence of the B-27 allele (n = 20) was associated with complete protection against disease progression and CNS impairment over the median follow-up of 26 months (P < 0.0001 for both). These findings held in multivariate analyses controlling for baseline covariates including race, gender, age, log HIV-1 RNA, CD4 lymphocyte count and percent, weight for age z score and treatment, and for other genotypes shown to affect HIV-1-related disease progression. Also, although the Cw-2 allele protected against disease progression [Hazard ratio (HR), 0.48; 95% confidence interval (CI): 0.28 to 0.81; P = 0.006], the ...Continue Reading


Jan 12, 1996·Science·R M Zinkernagel
Mar 1, 1996·QJM : Monthly Journal of the Association of Physicians·A J McNeilJ R Robertson
Mar 12, 1999·Science·M CarringtonS J O'Brien
May 26, 1999·The Journal of Infection·P J Easterbrook
Mar 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·S A MiguelesM Connors
Sep 7, 2000·The New England Journal of Medicine·J Klein, A Sato
Sep 14, 2000·The New England Journal of Medicine·J Klein, A Sato
Apr 20, 2001·Nature·A J McMichael, S L Rowland-Jones
Jan 31, 2002·Annual Review of Medicine·Rajesh T Gandhi, Bruce D Walker
Apr 16, 2002·AIDS·Geraldine M A GillespieSarah L Rowland-Jones
Jul 12, 2002·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Philip J Norris, Eric S Rosenberg
Jul 27, 2002·Annual Review of Genomics and Human Genetics·Michael DeanStephen J O'Brien
Jan 15, 2003·Annual Review of Medicine·Mary Carrington, Stephen J O'Brien
Apr 16, 2009·Clinical Microbiology Reviews·Jenefer M BlackwellDavid Burgner
Jan 12, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Salix BouletNicole F Bernard
Nov 19, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·María SalgadoBerta Rodés

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