HLA and age of onset in myasthenia gravis

Neuromuscular Disorders : NMD
Ernestina SantosBerta Martins da Silva

Abstract

The aetiology of MG is unknown, but both genetic and environmental factors are important. Over the years association of MG with Human Leucocyte Antigens (HLA) has been described in different populations. We investigated a possible association between HLA-DRB1 alleles and age of onset in MG. One hundred and fourteen MG patients (82 females) and 282 control individuals (CP) were studied. Patients were classified according to the age of onset (early-onset <50, n = 74 and late-onset ≥ 50, n = 20). Patients with thymoma (n = 20) were analyzed separately. HLA-DRB1 and HLA-B*08 genotyping was performed using PCR-SSP methodology. HLA-DRB1*03 allele was overrepresented in the global MG. When the early-onset subgroup was considered, this association became even stronger. Regarding the late-onset subgroup, the frequency of HLA-DRB1*01 allele was higher than in the CP. For the thymoma subgroup, the HLA-DRB1*10 allele frequency was significantly higher when compared to the CP. These results have shown a strong association of HLA-DRB1*03 with MG, especially for EOMG also in our population. HLA-DRB1*01 was associated to LOMG suggesting that is a susceptibility factor for this subgroup of the disease. This study confirms a different genetic ba...Continue Reading

Citations

Jan 9, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Cai-Se LingGong-Hao He
Dec 8, 2019·Acta neurologica Belgica·Senay Yildiz CelikFeza Deymeer
Nov 22, 2017·Immunology·Maneesh K MisraJill A Hollenbach
Mar 5, 2020·Auto- Immunity Highlights·Sergio Muñiz-CastrilloJérôme Honnorat
May 3, 2019·Muscle & Nerve·Ernestina SantosMaria Isabel Leite
Nov 19, 2020·Muscle & Nerve·Donald B SandersJanice M Massey
Feb 7, 2021·Annals of Clinical and Translational Neurology·Gregorio SpagniCarlo Provenzano
Feb 7, 2021·Archives of Biochemistry and Biophysics·Mariela L Paz, Francisco J Barrantes
Aug 3, 2021·The Annals of Thoracic Surgery·Shruti M RajaJacob A Klapper

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