PMID: 6965077Mar 1, 1980Paper

HLA and autism

Journal of Autism and Developmental Disorders
E G Stubbs, R E Magenis

Abstract

The authors, along with other investigators, postulate that viruses may be one of the causes of the syndrome of autism. Many diseases, especially those where a viral infection and autoimmunity is suspected, are being studied to determine whether an association with histocompatibility antigens (human leukocyte antigens--HLA) exists. The authors studied HLA in autism to see if a relationship exists. Twenty autistic children and their parents were HLA typed. The control group consisted of 575 potential donors for renal transplantation, 134 healthy subjects, and 48 persons of different families who married into one large family that had been HLA typed. The control subjects were from the same geographical area as the experimental subjects. Subjects were typed by a modification of the microlymphocytotoxicity tests of Terasaki and McCleland (1964). HLA-A2 was increased when compared to geographical controls, chi 2 = 5.020, p less than .05, and when compared to controls from the literature, chi 2 = 3.88, p less than .05. However, when chi 2 is corrected for the number of antigen specificities, significance is lost. No antigen was significantly increased in the mothers. HLA-A10 was significantly increased in the fathers, chi 2 = 5.947, ...Continue Reading

References

Jun 25, 1977·Lancet·A A Rimm, M M Bortin
Aug 9, 1969·Lancet·R Harris, E O Ukaejiofo
Dec 5, 1964·Nature·P I TERASAKI, J D MCCLELLAND

❮ Previous
Next ❯

Citations

Dec 1, 1988·Journal of Autism and Developmental Disorders·M LeboyerP Roubertoux
Jul 21, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Milo CareagaPaul Ashwood
Sep 5, 1981·Lancet·G Stubbs
Sep 5, 1981·Lancet·E Cotlier, Y R Sharma
Feb 6, 2002·Brain Research Bulletin·Christian Andres
Aug 29, 2012·Autism Research and Treatment·Anthony R TorresAllen J Rosenspire
Dec 30, 2004·American Journal of Public Health·Raymond F PalmerDavid S Mandell
Mar 1, 1985·Journal of the American Academy of Child Psychiatry·E G StubbsA Mason-Brothers
Jan 24, 2007·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Mao Sheng Yang, Michael Gill
Jul 5, 2012·Developmental Neurobiology·Leigh A Needleman, A Kimberley McAllister
May 25, 2006·Human Immunology·Anthony R TorresDennis Odell
Mar 29, 2014·Autism Research and Treatment·Manan Al-HakbanyLaila Al-Ayadhi
Jul 23, 2013·Journal of Autoimmunity·Benjamin GesundheitPaul Ashwood
Nov 5, 2016·Frontiers in Neuroscience·Anthony R TorresMichael Benson
Jun 5, 2019·Acta Neuropsychiatrica·Nina StrennAgneta Ekman
Oct 2, 2019·Frontiers in Psychiatry·Terry HarvilleRichard E Frye

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.