Since the first association between HLA and diseases of native kidneys was described almost 50 years ago, technological and conceptual advances in HLA biology and typing, together with better case ascertainment, have led to an improved understanding of HLA associations with a variety of renal diseases. A substantial body of evidence now supports the existence of HLA genetic associations in the field of renal disease beyond the role of HLA in allogeneic responses in transplant recipients. Allomorphs of HLA have emerged as important risk factors in most immune-mediated renal diseases, which, together with other genetic and environmental factors, lead to loss of tolerance and autoimmune-mediated renal inflammation. HLA associations have also been described for renal diseases that are less traditionally seen as autoimmune or immune-mediated. Here, we review essential concepts in HLA biology and the association of HLA with diseases of the native kidneys, and describe the current understanding of the epistatic and mechanistic bases of HLA-associated kidney disease. Greater understanding of the relationship between HLA and kidney function has the potential not only to further the understanding of immune renal disease at a fundamental ...Continue Reading
HLA-antigens in long standing insulin dependent diabetics with terminal nephropathy and retinopathy with and without loss of vision
Predominant expression and activation-induced tyrosine phosphorylation of phospholipase C-gamma 2 in B lymphocytes
The DQw7 allele at the HLA-DQB locus is associated with susceptibility to IgA nephropathy in Caucasians
Genes encoding the beta-chains of HLA-DR7 and HLA-DQw2 define major susceptibility determinants for idiopathic nephrotic syndrome
Associations between HLA antigens and nephrotic syndrome in African and Indian children in South Africa
Quantitative studies on the mixed lymphocyte interaction in rats. VI. Reactivity of lymphocytes from conventional and germfree rats to allogeneic and xenogeneic cell surface antigens
Increased expression of HLA-DR antigens on renal tubular cells in renal transplants: relevance to the rejection response
HLA-DR antigens and toxic reaction to sodium aurothiomalate and D-penicillamine in patients with rheumatoid arthritis
Strong association of idiopathic membranous nephropathy (IMN) with HLA-DR 3 and MT-2 without involvement of HLA-B 18 and no association to BfF1
An analysis of HLA class II gene polymorphism in British and Greek idiopathic membranous nephropathy patients
HLA class II typing and idiopathic IgA nephropathy (IgAN): DQB1*0301, a possible marker of unfavorable outcome
Associations of HLA-DR and HLA-DQ types with anti-GBM nephritis by sequence-specific oligonucleotide probe hybridization
Susceptibility to anti-glomerular basement membrane disease is strongly associated with HLA-DRB1 genes
D-penicillamine-induced crescentic glomerulonephritis and antimyeloperoxidase antibodies in a patient with scleroderma. Case report and review of the literature
Cathepsin S and Protease-Activated Receptor-2 Drive Alloimmunity and Immune Regulation in Kidney Allograft Rejection
Formation of the Australia and New Zealand Vasculitis Society to improve the care of patients with Vasculitis in Australian and New Zealand.
Human leukocyte antigen associations with renal function among ethnic minorities in the United Kingdom.
HLA-DQ and HLA-DRB1 alleles associated with Henoch-Schönlein purpura nephritis in Finnish pediatric population: a genome-wide association study.
Recurrent membranous nephropathy after transplantation: donor antigen and HLA converge in defining risk.
Bioinformatic HLA Studies in the Context of SARS-CoV-2 Pandemic and Review on Association of HLA Alleles with Preexisting Medical Conditions.
Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.