HLA and sporadic tuberculoid leprosy: a population study in Maharashtra, India

Tissue Antigens
W van EdenJ J Van Rood

Abstract

A population study to test whether associations between HLA and sporadic--i.e. non-familial--tuberculoid leprosy exist was undertaken in a hyperendemic area in India. Since previous family studies in the same area had shown both non-random haplotype segregation in the family members affected with tuberculoid leprosy and the preferential segregation of HLA-DR2 into tuberculoid leprosy patients, an increased frequency of DR2 among the "sporadic" patients was expected. However, no heterogeneity for HLA was detected between patients and controls. These findings could indicate that tuberculoid leprosy is a heterogeneous disease with regard to genetic background.

References

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Mar 1, 1987·Archives of Disease in Childhood·H J BodanskyD Haigh
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Jun 15, 2007·Revista Da Sociedade Brasileira De Medicina Tropical·Fabiana Covolo de SouzaMaria Esther Salles Nogueira
Aug 27, 2005·European Journal of Epidemiology·Yogita GhodkeBhushan Patwardhan

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