HLA antigen frequencies in cirrhotic and noncirrhotic male alcoholics: a controlled study

Alcoholism, Clinical and Experimental Research
R T RadaM Richards

Abstract

Although epidemiological data suggest that the development of cirrhosis in alcohol abusers is related to the duration and amount of ethanol intake, the fact that only a small percentage of alcohol abusers develop cirrhosis remains unexplained and suggests a possible predisposing genetic factor. Several previous studies have reported an association between various human leucocyte antigens (HLA) and alcoholic cirrhosis. In this study HLA antigen frequencies were determined in Anglo- and Spanish-American cirrhotic and noncirrhotic alcoholics and in a control group of nonalcoholic patients without liver disease. No statistically significant differences in HLA frequencies among the groups were found. Our comparisons of HLA frequencies between cirrhotic and noncirrhotic alcoholic patients do not support the hypothesis that individual susceptibility to the development of alcoholic cirrhosis is genetically determined.

References

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Citations

Dec 17, 1983·British Medical Journal·J B Saunders
May 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M DoffoelR Bockel
Oct 1, 1986·Alcoholism, Clinical and Experimental Research·R D Johnson, R Williams
Aug 1, 1986·Alcoholism, Clinical and Experimental Research·R R WatsonB Hartmann

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