HLA antigens expressed on human erythroid burst forming cells

Tissue Antigens
Y OheK Nagai

Abstract

The human major histocompatibility antigens HLA, play an important role in transplantation. To ascertain the expression of the antigens of A and B loci on the surface of human hemopoietic progenitors, the cytotoxic effect of specific anti-HLA sera was examined. Anti-HLA A2 and B5 sera were used in the present experiments. Circulating blood mononuclear cells and nucleated marrow cells, pretreated with appropriate specific anti-HLA sera and complement, formed fewer colonies from BFU-e and CFU-c in a culture medium than the controls which were treated with autologous serum. In our experiments, the HLA antisera also killed macrophages, monocytes, and T cells which carry the surface antigen. Then, the influence of macrophages, monocytes, and T cells on colony formation from BFU-e and CFU-c was examined. These results indicated that BFU-e as well as CFU-c expressed HLA antigens on their surface.

References

Feb 1, 1978·The Journal of Experimental Medicine·D G NathanD E Housman
Nov 1, 1978·The Journal of Experimental Medicine·I GoldschneiderR J Morris
Apr 1, 1979·European Journal of Immunology·G BrownD Y Mason
Dec 8, 1977·Nature·R S BaschM F Greaves
Aug 1, 1978·The Journal of Experimental Medicine·R J WinchesterH G Kunkel
Jan 20, 1973·Lancet·J WybranH H Fudenberg
Jan 1, 1974·Tissue Antigens·K M Cook
Aug 1, 1972·The Journal of Experimental Medicine·E S Golub
Nov 1, 1972·The Journal of Clinical Investigation·D W Golde, M J Cline
Dec 5, 1964·Nature·P I TERASAKI, J D MCCLELLAND

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Citations

Aug 1, 1992·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·I Gudmundsdóttir, H M Ogmundsdóttir

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