PMID: 6405574Apr 1, 1983Paper

HLA antigens in a family with both parents and several siblings affected by Graves' disease

Acta Endocrinologica
M Fernández CastañerM G Ercilla

Abstract

A family with autoimmune thyroid disease is described. Four members had Graves' disease and 3 had diffuse goitres. Both parents (second cousins) carry the HLA haplotype: HLA Aw24, Bw39(w6), Cw-, DR3, MT2. Only females with this haplotype show thyroid symptoms. These findings emphasize the involvement of HLA linked genes in susceptibility to Graves' disease.

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