PMID: 7039491Jan 1, 1982Paper

HLA antigens in four Pacific populations with non-insulin-dependent diabetes mellitus

Annals of Human Biology
S W SerjeantsonG Le Gonidec

Abstract

HLA antigen distributions in persons with normal and abnormal glucose tolerance were compared in four Pacific populations. The populations included Melanesians from the Fijian Islands, Loyalty Islands and mainland New Caledonia and Polynesians from the Wallis Islands. HLA-DR results are provided for the first time for Pacific groups. In Polynesians, HLA-B22 was increased in frequency in patients with non-insulin-dependent diabetes mellitus and also in persons with impaired glucose tolerance. However, the association was not statistically significant when corrected for the number of antigens tested. A similar increase in HLA-B22, although not significant, was seen in each of the three Melanesian populations with abnormal glucose tolerance. No other consistent increase in any HLA antigen occurred in persons with abnormal plasma glucose concentrations.

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Citations

Jul 1, 1992·Tissue Antigens·X GaoS W Serjeantson
Dec 1, 1990·Diabetes/metabolism Reviews·K L RamaiyaK G Alberti
Apr 1, 1992·Journal of Cellular Biochemistry·C Bogardus, S Lillioja
Jan 1, 1984·Critical Reviews in Clinical Laboratory Sciences·C M Zmijewski
Apr 1, 1984·Tissue Antigens·D KostyuB Amos
Nov 17, 1988·The New England Journal of Medicine·S M HaffnerJ K Patterson
Jun 1, 1986·Australian and New Zealand Journal of Medicine·P ZimmetR Kirk
Apr 1, 1985·Human Immunology·G CraneH Bashir
Apr 1, 1984·Human Immunology·K BhatiaG Koki

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