PMID: 6401993Jan 1, 1983Paper

HLA antigens in juvenile arthritis. Genetic basis for the different subtypes

Arthritis and Rheumatism
O FørreE Thorsby

Abstract

Serologic HLA typing was performed in 77 patients with juvenile arthritis (JA). The frequency of the DR4 antigen was significantly increased in the seropositive but decreased in the seronegative patients--53% and 17%, respectively (P less than 0.025)--compared with 27% in healthy Norwegians. An increased frequency of the HLA-DR4 antigens was also found in polyarticular onset JA (50% compared with 27%, P less than 0.05). The frequency of both the HLA-B27 (21%) and the DR5 antigen (21%) was increased in the whole patient group compared with controls (10% and 9%, respectively, P less than 0.01). The DR5 antigen was also increased in the systemic onset patients (40%, P less than 0.05). Both the DR5 and the DR8 antigens were increased in the pauciarticular onset group (P less than 0.05 and P less than 0.01, respectively). The results support the view that seropositive and seronegative JA are different disease entities and also that seropositive JA may be an early form of seropositive rheumatoid arthritis. The association between the DR4 antigen and IgM rheumatoid factor suggests that the HLA-DR4 gene or a closely linked gene may regulate autoimmune responses to self IgG.

References

Sep 1, 1978·British Medical Bulletin·A Munro, H Waldmann
Jan 1, 1979·The Journal of Clinical Investigation·P Stastny, C W Fink
Oct 1, 1977·Tissue Antigens·M E GershwinT A Gorman
Apr 18, 1974·The New England Journal of Medicine·G S RachelefskyE R Stiehm
Jul 1, 1980·Arthritis and Rheumatism·D N Glass, D A Litvin

❮ Previous
Next ❯

Citations

Nov 11, 1999·Arthritis and Rheumatism·D N Glass, E H Giannini
Dec 1, 1985·Clinical Rheumatology·R MarcolongoF Fantini
Jan 1, 1995·Immunologic Research·L I Sakkas, C D Platsoucas
Mar 5, 2005·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·C SenglerU Pleyer
Jul 29, 2010·Zeitschrift für Rheumatologie·J P Haas
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M L MillerD N Glass
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A B BegovichH A Erlich
Jan 1, 1997·Tissue Antigens·I RumbaC B Sanjeevi
Jun 1, 1996·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·R P Donn, W E Ollier
Feb 1, 1986·Archives of Disease in Childhood·A M LeakS J Burman
Jun 15, 2007·Pediatric Rheumatology Online Journal·James N JarvisMichael Centola
Jul 23, 2008·Pediatric Rheumatology Online Journal·Sampath Prahalad, David N Glass
Sep 28, 2006·Arthritis Research & Therapy·James N JarvisMichael Centola
Apr 25, 2007·Scandinavian Journal of Rheumatology·C PruunsildP Pelkonen
Sep 1, 1994·Journal of the American Academy of Dermatology·A FiroozA R Ahmed
Jan 1, 1987·Epilepsia·M MinevL Belopitova
Dec 1, 1988·Baillière's Clinical Rheumatology·W P Maksymowych, D N Glass
Jul 6, 2014·Ocular Immunology and Inflammation·Sebastiaan J VastertDebra A Goldstein
Jan 1, 1987·Scandinavian Journal of Rheumatology. Supplement·P Møller
Aug 1, 1997·Rheumatic Diseases Clinics of North America·R Burgos-VargasJ Vázquez-Mellado
Jan 1, 1987·Scandinavian Journal of Rheumatology. Supplement·E Albert, B M Ansell
Jan 1, 1984·Scandinavian Journal of Rheumatology. Supplement·J Friis
May 3, 2000·International Ophthalmology Clinics·K YabukiS Ohno
Jan 31, 2006·Tissue Antigens·Z LombardL Bornman
Jun 7, 2019·Current Opinion in Rheumatology·Peter A NigrovicSusan D Thompson
Nov 1, 1984·Arthritis and Rheumatism·A Arnaiz-VillenaI Mateo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.