PMID: 11903375Mar 21, 2002Paper

HLA associations with nasopharyngeal carcinoma in Southern Chinese: a meta-analysis

Clinical Otolaryngology and Allied Sciences
D B GoldsmithRandall Morton

Abstract

The literature relating to human leucocyte antigens (HLA) and nasopharyngeal carcinoma (NPC) identifies conflicting ranges of possible allelic associations. We aimed to clarify this by conducting a systematic review to identify and quantify associations present across all of the available studies. A literature search was performed and, subsequently, a meta-analysis was performed on 13 published studies using both fixed-effects and random-effects models when appropriate. Evidence for positive associations between NPC and the HLA alleles A2, B14 and B46 (P = 1.57 x 10-5, 1.13 x 10-3 and 6.38 x 10-5 respectively) were found, and negative associations were identified for the alleles A11, B13 and B22 (P = 5.42 x 10-3, 0.017 and 0.009). Whereas an association between HLA-B13 or B22 and NPC has not been noted previously, the results for HLA-A2, A11, B14 and B46 are in accordance with published studies. There is evidence that specific allele subtypes or combinations of alleles may carry particular risk for NPC.

References

Aug 15, 1975·International Journal of Cancer. Journal International Du Cancer·H BetuelG de-Thé
Nov 18, 1989·Lancet·R P Morton, C S Benjamin
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Mar 1, 1985·British Journal of Cancer·S H ChanN Kunaratnam
Nov 15, 1971·International Journal of Cancer. Journal International Du Cancer·C S Muir
Nov 1, 1973·Journal of the National Cancer Institute·T M LinT Hirayama
May 15, 1970·International Journal of Cancer. Journal International Du Cancer·P Clifford
Aug 15, 1983·International Journal of Cancer. Journal International Du Cancer·S H ChanM J Simons
Oct 9, 1995·International Journal of Cancer. Journal International Du Cancer·E C RenS H Chan
Apr 22, 1997·International Journal of Cancer. Journal International Du Cancer·E E OoiS H Chan
Mar 24, 1998·The Journal of Laryngology and Otology·H HuangW Wu

❮ Previous
Next ❯

Citations

Nov 25, 2006·Cancer Immunology, Immunotherapy : CII·Maurizio ProvenzanoFrancesco M Marincola
Sep 1, 2007·Head and Neck Pathology·Lester D R Thompson
Jul 29, 2008·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Luke R RudmikJoseph Dort
Dec 29, 2004·Pathologie-biologie·H BoussenA Ladgham
Oct 3, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J-P SpanoJ-P Armand
Nov 27, 2002·Seminars in Cancer Biology·Kwok-Wai Lo, Dolly P Huang
May 3, 2003·Trends in Molecular Medicine·Stanislav VukmanovićFabio R Santori
May 30, 2009·Journal of Human Genetics·Ching Ching NgTaisei Mushiroda
Jan 21, 2006·Journal of Translational Medicine·Xin LiFrancesco M Marincola
May 8, 2007·Journal of Translational Medicine·Xin LiFrancesco M Marincola
Jun 19, 2009·Journal of Translational Medicine·Hideaki TaharaFrancesco M Marincola
Dec 25, 2012·Yi chuan = Hereditas·Min-Zhong TangYi Zeng
Oct 22, 2014·Carcinogenesis·Dan Chen, Ulf Gyllensten
Jun 19, 2009·International Journal of Cancer. Journal International Du Cancer·Elisa PasiniRiccardo Dolcetti
May 1, 2008·Head & Neck·Josephine ChouDavid M Jablons
Mar 4, 2008·International Journal of Immunogenetics·K FarhatL Chouchane
Mar 1, 2014·Reviews in Medical Virology·Takayuki MurataHiroshi Kimura
Jul 22, 2006·Oral Oncology·Judith ReindersMarcel G J Tilanus
May 16, 2006·Human Immunology·Judith ReindersMarcel G J Tilanus
Jun 21, 2014·International Journal of Cancer. Journal International Du Cancer·Yoon-Ming ChinChing-Ching Ng
Jul 3, 2008·The Journal of the American Dental Association·William James Maloney, Mea A Weinberg
Mar 15, 2015·Seminars in Diagnostic Pathology·Fredrik Petersson
Aug 29, 2009·Molecular Biology Reports·Hafedh MakniMounir Frikha
May 2, 2019·Frontiers in Pediatrics·Yasuaki HarabuchiTakumi Kumai
Jan 1, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Sitakan NatphopsukDariwan Settheetham
Jun 9, 2004·International Journal of Cancer. Journal International Du Cancer·Amy PickardAllan Hildesheim
May 19, 2009·Molecular Biology Reports·Elham HassenLotfi Chouchane
Apr 15, 2021·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Ellen T ChangHans-Olov Adami

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.