HLA-B15: a widespread and diverse family of HLA-B alleles

Tissue Antigens
W H HildebrandP Parham

Abstract

HLA-B15 embraces a multiplicity of antigenic specificities which vary in their distribution amongst human populations. To correlate B15 molecular structure with the serological picture we have sequenced alleles encoding the various subspecificities of the B15 antigen: B62, B63, B75, B76 and B77, and a number of "variants" of these antigens including the 8w66 split of B63. HLA-B63 (B*1517) and 8w66 (B*1516) heavy chains have sequence identity to B17 in the alpha 1 helix correlating with the antigenic crossreactivity of these molecules. HLA-B77(B*1513) and B75 (B*1502) heavy chains differ solely in segments determining the Bw4 and Bw6 public epitopes, consistent with the serological description of the B77 and B75 antigens. One allele encoding the B76 antigen (B*1512) appears to be the product of gene conversion between the HLA-A and -B loci and differs from B*1501 in codons 166 and 167. In contrast, a second allele encoding the B76 antigen (B*1514) differs from B*1501 by an unrelated substitution in codon 167 which confers similarily with B45, an antigen crossreactive with B76. A third allele encoding B76, B*1519, differs from B*1512 by a unique point substitution in exon 4. Three alleles encoding variant B15 and B62 antigens (B*...Continue Reading

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Citations

Sep 1, 1994·Human Immunology·J G BodmerT Sasazuki
Jul 1, 1997·Human Immunology·J WangP Stastny
Aug 1, 1997·Human Immunology·N SteinerC K Hurley
Jan 23, 1998·Human Immunology·D D KostyuD V Dawson
Dec 22, 1999·Tissue Antigens·K R PrillimanW H Hildebrand
Jun 1, 1995·The Journal of Experimental Medicine·J A McCutcheonP Parham
Jul 1, 1994·Tissue Antigens·J G BodmerT Sasazuki
Mar 1, 1995·Tissue Antigens·M Fernandez-ViñaP Stastny
Apr 1, 1996·Tissue Antigens·L LinT Juji
Dec 1, 1996·Tissue Antigens·K HirayamaJ W Mak
Jul 1, 1997·Tissue Antigens·C DarkeP Parham
Feb 11, 1998·Tissue Antigens·C Y MarcosP Stastny
Nov 5, 1998·Tissue Antigens·N YuE J Yunis
Jan 1, 1994·Vox Sanguinis·J G BodmerT Sasazuki
Jan 1, 1996·Transplant International : Official Journal of the European Society for Organ Transplantation·S K HemmatpourW M Howell
Feb 1, 1995·Immunological Reviews·P ParhamK L Arnett

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