HLA B27-associated rheumatic diseases with severe cardiac bradyarrhythmias. Clinical features and prevalence in 223 men with permanent pacemakers

The American Journal of Medicine
L Bergfeldt


A 15-fold increase in the prevalence of ankylosing spondylitis in a group of 223 men with permanent cardiac pacemakers has recently been demonstrated. In this study of the same patient group, the prevalence of other related rheumatic syndromes was investigated by clinical examination and HLA typing. The clinical picture and electrocardiographic features of all patients with HLA B27-associated rheumatic disease (seronegative spondarthritis) were analyzed. Altogether 28 patients, 12.6 percent (95 percent confidence limits: 8.2 to 17.0 percent), fulfilled inclusion criteria for seronegative spondarthritides; 15 had ankylosing spondylitis. The seronegative spondarthritides previously had been diagnosed in less than 50 percent of the patients. Twenty-two (85 percent) of the 26 HLA-typed patients were B27-positive, implying a very strong association with this genetically determined cell surface protein. Patients with severe bradyarrhythmias associated with the seronegative spondarthritides were thus found to constitute a large proportion of the 223 men with permanent pacemakers. A high frequency of aortic regurgitation and all kinds of bradyarrhythmias were found. Twenty patients had complete heart block--in a majority, occurring int...Continue Reading


Jul 1, 1979·American Heart Journal·R ThompsonM Yacoub
Dec 1, 1977·Archives of Dermatology·F ErsoyH Kazokoğlu
Dec 28, 1978·The New England Journal of Medicine·S R StewartJ J Castles
Apr 5, 1973·The New England Journal of Medicine·L SchlossteinC M Pearson
Jun 1, 1981·American Journal of Ophthalmology·A TiilikainenR Frants


Dec 25, 2012·Zeitschrift für Rheumatologie·A InanirH Kadi
Feb 3, 1999·Baillière's Clinical Rheumatology·W al-Khonizy, J D Reveille
Jun 1, 1991·Annals of the Rheumatic Diseases·A J PeetersB A Dijkmans
Jul 1, 1991·Postgraduate Medical Journal·J E Elizabeth, G J Green
Dec 28, 2010·Joint, Bone, Spine : Revue Du Rhumatisme·Carlo PalazziIgnazio Olivieri
Dec 19, 2006·Archives of Medical Research·Leszek MarkuszeskiAnna Zalewska
Feb 1, 1987·The American Journal of Medicine·L Bergfeldt, E Möller
Jan 26, 1999·Clinics in Chest Medicine·M J Longo, M S Remetz
Jul 1, 1985·The American Journal of Medicine·D J O'Donoghue
Jul 1, 1988·Angiology·M G AlvesE Macieira-Coelho
Jan 25, 2008·Angiology·Jaroslaw KazmierczakMarek Brzosko
May 1, 1988·Annals of the Rheumatic Diseases·R A HoppmannJ E Peacock
Dec 17, 2002·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Andrew Jaworski, Angeliki Arvanitis
Jan 15, 2014·Expert Review of Clinical Immunology·Francesca IngegnoliEnnio Lubrano
May 1, 1983·Tissue Antigens·L Bergfeldt, E Möller

Related Concepts

Aortic Valve Insufficiency
Cardiac Arrhythmia
Cardiac Pacing, Artificial
Heart Block
HLA Antigens
Myocardial Infarction
Sacroiliac Joint Structure
Ankylosing Spondylitis
HLA Class I Histocompatibility Antigen, B-27 alpha Chain

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.


Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.


Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.