PMID: 6983709Jan 1, 1982Paper

HLA-B27 in possible ankylosing spondylitis with peripheral arthritis

Rheumatology International
H ZeidlerH Deicher

Abstract

Among 86 patients selected as possibly having ankylosing spondylitis because of clinical symptoms and radiologically normal sacroiliac joints. HLA-B27 was positive in 41%. Four years later a representative sample of 38 individuals were re-examined and radiographed. HLA-B27 positive patients developed sacroiliitis as defined by radiological criteria twice as often (P less than 0.05). They also showed increased uptake of technetium 99 m upon quantitative scintigraphy with a region of interest method and more often probable or definite ankylosing spondylitis as defined by the New York criteria. Further differences between the HLA-B27 positive and negative follow-up groups concerned the frequency of clinical symptoms and peripheral arthritis. It is suggested that HLA-B27 typing may be helpful both in diagnosis and in judging the prognosis of possible or abortive ankylosing spondylitis.

References

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Citations

Sep 1, 1987·Clinical Rheumatology·W MauH Deicher
Jan 1, 1989·Rheumatology International·M GalloG Tirri
Jan 1, 1987·Scandinavian Journal of Rheumatology. Supplement·H Zeidler
Jul 1, 1990·Biulleten' eksperimental'noĭ biologii i meditsiny·V I Kresiun, Ia V Rozhkovskiĭ
Jan 1, 1984·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·Z SchaffR J Gerety

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