HLA Class I and Class II Alleles and Haplotypes Confirm the Berber Origin of the Present Day Tunisian Population

PloS One
A HajjejS Hmida

Abstract

In view of its distinct geographical location and relatively small area, Tunisia witnessed the presence of many civilizations and ethnic groups throughout history, thereby questioning the origin of present-day Tunisian population. We investigated HLA class I and class II gene profiles in Tunisians, and compared this profile with those of Mediterranean and Sub-Sahara African populations. A total of 376 unrelated Tunisian individuals of both genders were genotyped for HLA class I (A, B) and class II (DRB1, DQB1), using reverse dot-blot hybridization (PCR-SSO) method. Statistical analysis was performed using Arlequin software. Phylogenetic trees were constructed by DISPAN software, and correspondence analysis was carried out by VISTA software. One hundred fifty-three HLA alleles were identified in the studied sample, which comprised 41, 50, 40 and 22 alleles at HLA-A,-B,-DRB1 and -DQB1 loci, respectively. The most frequent alleles were HLA-A*02:01 (16.76%), HLA-B*44:02/03 (17.82%), HLA-DRB1*07:01 (19.02%), and HLA-DQB1*03:01 (17.95%). Four-locus haplotype analysis identified HLA-A*02:01-B*50:01-DRB1*07:01-DQB1*02:02 (2.2%) as the common haplotype in Tunisians. Compared to other nearby populations, Tunisians appear to be geneticall...Continue Reading

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Citations

Feb 9, 2016·Immunological Investigations·Batoul JazairiHossam Murad
Nov 25, 2016·Journal of Human Genetics·Abdelhafidh HajjejSlama Hmida
Mar 10, 2018·PloS One·Abdelhafidh HajjejSlama Hmida
Jun 5, 2019·Immunological Investigations·Monia MessoussiKarima Fadhlaoui-Zid
Apr 18, 2018·Molecular Genetics & Genomic Medicine·Houda Elloumi-Zghal, Habiba Chaabouni Bouhamed
Mar 15, 2019·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Reem AmeenSteven G E Marsh

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Methods Mentioned

BETA
genotyping
dot blot
PCR

Software Mentioned

VISTAV5
Arlequin
DISPAN

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