HLA class I and II in black children with hepatitis B virus-associated membranous nephropathy

Kidney International
Rajendra BhimmaCatherine A Connolly

Abstract

The pathogenetic mechanisms by which individuals with chronic hepatitis B virus (HBV) infection develop membranous nephropathy (MN) are probably dependent on interactions between viral, host and environmental factors; some evidence suggests a genetic predisposition. HBVMN constitutes a major etiological group in black children with nephrotic syndrome. We therefore explored the HLA associations in black children with HBVMN. Thirty black children, age range 2 to 16 years, with biopsy-proven HBVMN, were the subjects of the study. HBV status was determined using third generation ELISA. HLA A, B and C antigens were determined using a two-stage lymphocytotoxic test. HLA DRB1* and DQB1* typing was done using sequence-specific primers. HLA class 1 and II antigen frequencies of the study subjects were compared to controls that were randomly chosen healthy blood donors from the same population. HLA DQB1*0603 was increased in patients with HBVMN compared to controls (chi2 = 13.65, RR = 4.3). DRB1*07 and DQB1*02 were increased in frequency in the study subjects but failed to reach statistical significance. There was no significant difference in the frequencies of class 1 antigens in the study group compared to controls. To our knowledge, t...Continue Reading

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Citations

Mar 16, 2011·European Journal of Internal Medicine·Gaosi Xu, Tianlun Huang
Jan 31, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Gyu-Tae ShinHeungsoo Kim
Jan 31, 2006·Tissue Antigens·Z LombardL Bornman
Jul 13, 2004·Journal of Hepatology·Mohammed S JazayeriWilliam F Carman
Aug 28, 2015·Advances in Chronic Kidney Disease·Anu Gupta, Richard J Quigg
Jul 9, 2004·World Journal of Gastroenterology : WJG·Guo-Qing ZangZheng-Hao Tang
Jul 7, 2018·Immunological Investigations·Horea Vladi MateiCostel Vasile Siserman
Sep 13, 2018·Nature Reviews. Nephrology·Kate J RobsonA Richard Kitching

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