PMID: 9174148May 1, 1997Paper

HLA class I genotyping by cDNA sequence of a Vietnamese family expressing a weak B46 antigen

Tissue Antigens
C M TzengP Parham

Abstract

Serological heterogeneity in HLA-B46 antigens has been described. Previous studies have identified B*4601 as the allele encoding the "strong" B46 antigen found in Chinese populations. Serological characterization of a Vietnamese family revealed a "weak" B46 antigen. Complementary DNA for the HLA-A, B and C alleles of three family members were cloned and the coding regions sequenced. The allele encoding the weak B46 antigen has the same coding sequence as B*4601, demonstrating that the antigenic differences are not due to polymorphism in the amino acid sequence of the HLA-B heavy chain. The recently described HLA-B*1525 and HLA-Cw*0403 alleles were also found to segregate in this Vietnamese family.

References

Apr 1, 1978·Tissue Antigens·P N Goodfellow, R O Payne
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Nov 1, 1992·European Journal of Pediatrics·C C ChangY L Lau
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·P D EnnisP Parham
Feb 1, 1982·Urology·T J WachtelJ Cossin
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Aug 1, 1996·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·S G Marsh
Sep 1, 1984·Immunology Today·J Bodmer, W Bodmer

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Citations

Mar 25, 1999·Tissue Antigens·E C RenJ Hansen
Dec 3, 2002·Nature Reviews. Genetics·Pat Simpson

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