PMID: 9438190Jan 23, 1998Paper

HLA class I polymorphism: structure and function and still questions

Human Immunology
D D KostyuD V Dawson

Abstract

The HLA-A, HLA-B and HLA-C molecules have turned out to be highly polymorphic and functionally complex. They not only serve as peptide receptors, but also interact with beta 2-microglobulin, an alpha beta T cell receptor, CD8 and NK inhibitory molecules, all at different sites. The fact that more than 300 class I alleles have now been defined prompted us to ask the question of where polymorphism really occurs in a class I molecule. We have used a database of 275 HLA-A, HLA-B and HLA-C alleles to illustrate how extensive the polymorphism is. The data is presented here for comparison of alleles and allele families and to facilitate studies of class I structure and function.

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Citations

Feb 19, 1999·Immunity·D N Garboczi, W E Biddison
Jun 7, 2000·Molecular Medicine Today·R A Colbert
Jun 16, 2011·Antioxidants & Redox Signaling·Antony N AntoniouSimon J Powis
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Sep 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zichun WangWilliam E Biddison

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