HLA class I-restricted and tumor-specific cytotoxic T lymphocytes from metastatic lymph nodes of esophageal cancers

Cellular Immunology
U TohK Itoh

Abstract

This paper investigates the presence of HLA class I-restricted and tumor-specific cytotoxic T lymphocytes (CTL) in tumor sites of esophageal cancers. Five CTL lines were established from the metastatic lymph nodes or pleural effusion by incubation with interleukin-2 of tumor-infiltrating lymphocytes: cases 1 and 5, HLA-A26- and HLA-A33-restricted and squamous cell carcinoma (SCC)-specific CTL; case 2, HLA-Cw0102-restricted and esophageal SCC-specific CTL; case 3, HLA-A24- and HLA-A26-restricted CTL recognizing histologically different tumor cells; and case 4, HLA-A26-restricted and esophageal SCC-specific CTL. These results suggest the existence of HLA class I-restricted and tumor-specific CTL in metastatic esophageal SCC.

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Citations

Aug 31, 1999·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·J O'ConnellF Shanahan
Nov 3, 2004·Vaccine·John R Yannelli, Joanne M Wroblewski
Sep 24, 2004·International Journal of Cancer. Journal International Du Cancer·Kazue NakashimaTakaki Hiwasa
Feb 29, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M NakaoK Itoh
Oct 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yoshihiro YoshitakeYasuharu Nishimura

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