PMID: 9448304Mar 14, 1998Paper

HLA class I-specific inhibitory receptors in human T lymphocytes: interleukin 15-induced expression of CD94/NKG2A in superantigen- or alloantigen-activated CD8+ T cells

Proceedings of the National Academy of Sciences of the United States of America
Maria Cristina MingariL Moretta

Abstract

A fraction of human T lymphocytes, predominantly CD8+, express receptors for HLA class I molecules typical of natural killer cells (natural killer receptors or NKRs) that inhibit T cell receptor-mediated functions. Herein, we analyzed possible mechanism(s) leading to the expression of NKRs by T cells responding to superantigens or allogeneic cells in vitro. We show that, in the presence of interleukin 15 (IL-15), T cells (depleted of NKR+ cells) responding to toxic shock syndrome toxin 1 de novo express CD94, a molecule that is part of a heterodimeric NKR with a broad specificity for different HLA class I alleles. Maximal CD94 expression occurred when IL-15 was added shortly after the cells were placed into culture, and CD94 expression started 4-6 days after addition of IL-15. Although both CD4+ and CD8+ cells expressed CD94, the simultaneous expression of NKG2A (i.e., the other component of the CD94/NKG2A inhibitory NKR) was confined to CD8+ cells. Similar data were obtained in T cell populations activated in mixed lymphocyte cultures in the presence of IL-15. The expression of CD94/NKG2A led to an impairment of allo-specific cytolytic activity by mixed lymphocyte culture-derived T cell populations or clones. Remarkably, cytol...Continue Reading

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Citations

Feb 18, 2006·Cancer Immunology, Immunotherapy : CII·Rafael SolanaRaquel Tarazona
May 4, 2010·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Eiji MatsuuraSteven Jacobson
Dec 31, 2003·Trends in Immunology·Melissa R SnyderJörg J Goronzy
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Jul 26, 2003·Immunology Letters·Lorenzo MorettaAlessandro Moretta
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Feb 5, 2000·Human Immunology·M López-BotetM de Miguel
Feb 5, 2000·Human Immunology·A De Maria, L Moretta
Apr 27, 2000·Current Opinion in Immunology·S Ugolini, E Vivier
Aug 11, 2001·Current Opinion in Immunology·C W McMahon, D H Raulet
Mar 14, 2003·Current Opinion in Immunology·Werner HeldJacques Zimmer
May 14, 1999·Current Opinion in Immunology·D H Raulet
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Mar 5, 2003·Trends in Immunology·Lorenzo MorettaMaria Cristina Mingari
Jun 23, 2010·Immunology and Cell Biology·Hollie J PegramMichael H Kershaw
Jun 15, 2011·Proceedings of the National Academy of Sciences of the United States of America·Marloes GoodenThorbald van Hall
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Mar 18, 2005·Annual Review of Immunology·Lewis L Lanier

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