HLA Class I Supertype Associations With Clinical Outcome of Secondary Dengue Virus Infections in Ethnic Thais

The Journal of Infectious Diseases
S VejbaesyaH A Stephens

Abstract

Human leukocyte antigen (HLA) supertypes are groups of functionally related alleles that present structurally similar antigens to the immune system. To analyze HLA class I supertype associations with clinical outcome in hospitalized Thai children with acute dengue illness. Seven hundred sixty-two patients and population-matched controls recruited predominantly in Bangkok were HLA-A and -B typed. HLA supertype frequencies were compared and tested for significant dengue disease associations using logistic regression analyses. Multivariable models were built by conducting forward stepwise selection procedures. In the final logistic regression model, the HLA-B44 supertype was protective against dengue hemorrhagic fever (DHF) in secondary infections (odds ratio [OR] = 0.46, 95% confidence interval [CI], .30-.72), while the HLA-A02 supertype (OR = 1.92, 95% CI, 1.30-2.83) and the HLA-A01/03 supertype (OR = 3.01, 95% CI, 1.01-8.92) were associated with susceptibility to secondary dengue fever. The B07 supertype was associated with susceptibility to secondary DHF in the univariate analysis (OR = 1.60, 95% CI, 1.05-2.46), whereas that was not retained in the final model. As the HLA-B44 supertype is predicted to target conserved epitopes...Continue Reading

References

Sep 1, 1981·The American Journal of Tropical Medicine and Hygiene·P ChiewsilpN Bhamarapravati
Jan 1, 1997·Immunology Today·R M Zinkernagel, P C Doherty
Apr 1, 1997·Human Immunology·D ChandanayingyongE Rungruang
Aug 1, 1997·The Journal of Infectious Diseases·S KalayanaroojF A Ennis
Apr 15, 1999·Tissue Antigens·S PozziG B Ferrara
Dec 23, 1999·The Journal of Infectious Diseases·D W VaughnA Nisalak
Jun 21, 2002·The Journal of General Virology·S Susanna TwiddyEdward C Holmes
Nov 25, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·John SidneyAlessandro Sette
Jan 23, 2004·Nature·Derek A T CummingsDonald S Burke
Feb 19, 2005·Nature Reviews. Immunology·Peter Parham
Aug 31, 2006·Current Opinion in Infectious Diseases·Sharone Green, Alan Rothman
Jan 24, 2008·BMC Immunology·John SidneyAlessandro Sette
Aug 14, 2008·PLoS Neglected Tropical Diseases·Asif M KhanJ Thomas August
Apr 28, 2009·The Journal of Infectious Diseases·Sasijit VejbaesyaHenry A F Stephens
Oct 6, 2009·Current Topics in Microbiology and Immunology·H A F Stephens
Apr 2, 2010·Tissue Antigens·S G E MarshJ Trowsdale
Apr 13, 2013·Proceedings of the National Academy of Sciences of the United States of America·Daniela WeiskopfAlessandro Sette

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Citations

Nov 13, 2015·Expert Review of Vaccines·Laura Rivino
Aug 10, 2016·Frontiers in Immunology·Laura Emily Hudson, Rachel Louise Allen
Jul 29, 2020·International Journal of Molecular Sciences·Pierpaolo CorrealeAntonio Giordano
Jul 7, 2021·PLoS Computational Biology·Maciej MigdalChristian Hammer
Apr 30, 2019·Analytical Chemistry·Sandip K PatelSanjeeva Srivastava

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