PMID: 11318984Apr 25, 2001Paper

HLA class II alleles in Chinese patients with hepatocellular carcinoma

Liver
P T DonaldsonP J Johnson

Abstract

Recent reports of an association between human leucocyte antigens (HLA) and persistence of hepatitis B virus infection, and the familial clustering of hepatocellular carcinoma raise the question of genetic susceptibility. Previous studies have been limited to serological phenotyping of HLA B and DR antigens. The aim of this study was to use molecular genotyping to investigate HLA class II as a risk factor for the development of hepatocellular carcinoma in Hong Kong Chinese. We determined HLA DRB1, DQA1, DQB1 and DPB1 alleles in 123 hepatitis B surface antigen positive patients (84 with hepatocellular carcinoma and 39 without) and 124 matched controls. The alleles DRB1*1501 (36% of HCC patients versus 19% of controls, odds ratio=2.44), DQA1*0102 (42% versus 26%, odds ratio=2.07), and DPB1*0501 (80% versus 63%, odds ratio=2.35) were significantly more common in patients with hepatocellular carcinoma, and DQA1*03 (36% versus 56%, odds ratio=0.53), DQB1*0302 (4.% versus 13%, odds ratio=0.25) and DPB1*0201 (14% versus 29%, odds ratio=0.4) were found at significantly lower frequencies. Although none of these associations was significant after correction for multiple testing, this report suggests that further investigations are warran...Continue Reading

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Citations

Jun 3, 2011·World Journal of Gastroenterology : WJG·Yong-Ning XinShi-Ying Xuan
Sep 29, 2011·The Kaohsiung Journal of Medical Sciences·Sheng-Chien TsaiBai-Hsiun Chen
Jun 19, 2009·International Journal of Cancer. Journal International Du Cancer·Elisa PasiniRiccardo Dolcetti
Nov 1, 2016·Scandinavian Journal of Gastroenterology·Hairong ZhuXizhong Shen
Apr 14, 2012·Journal of Clinical Gastroenterology·Young-Joo JinSoo Hyun Yang
May 26, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·Vanessa Villegas-Ruiz, Sergio Juarez-Mendez
Sep 30, 2008·Immunological Investigations·Farha A El-ChennawiZiyad E Tawhid
Mar 13, 2021·Immunogenetics·Guojin OuJue Wang

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