PMID: 12770797May 29, 2003Paper

HLA class II and TNF genes in African Americans from the Southeastern United States: regional differences in allele frequencies

Human Immunology
Tamara KuffnerJanet McNicholl

Abstract

Knowledge of population major histocompatibility complex gene frequencies is important for construction of organ donor pools and for studies of disease association. Human leukocyte antigen DRB1 (HLA-DRB1), HLA-DQB1, and TNFalpha -308 (G-A) promoter genetic typing was performed in 112 healthy, unrelated African Americans (AAs) from the southeastern United States. Allele frequencies were compared with published frequency data from other AA populations. Our AA population had the highest frequency of HLA- DRB1*09 (6.7%) reported in any AA population. The frequency of the TNF alpha -308A polymorphism was also high (14.4%), when compared with published frequencies in AAs. Significant regional differences in the distribution of most HLA-DRB1 and HLA-DQB1 alleles were observed in all AA populations examined. The AA HLA-DRB1 and -DQB1 frequencies also differed from published Caucasian frequencies. This is the first report describing the distribution of TNF alpha promoter alleles in the Southeastern United States. The high DRB1*09 and TNF alpha -308A allele frequencies of our population most resemble the frequencies of these alleles in certain West African populations. These varying major histocompatibility complex gene frequencies may r...Continue Reading

References

Mar 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A V HillM E Molyneux
Jun 1, 1991·Tubercle·V BrahmajothiR Prabhakar
Mar 1, 1989·The Journal of Infectious Diseases·G H BothamleyJ Ivanyi
Jan 1, 1989·Tissue Antigens·W OllierH Festenstein
Dec 1, 1996·Tissue Antigens·J J JustW Klitz
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·A G WilsonG W Duff
Apr 1, 1997·Molecular Immunology·K M KroegerL J Abraham
May 23, 1998·Annual Review of Immunology·A V Hill
Oct 8, 1998·Epidemiologic Reviews·M Szklo
Dec 5, 1998·Transplantation Proceedings·P C LeeP I Terasaki
May 1, 1999·Tropical Medicine & International Health : TM & IH·H A StirnadelH P Beck
Oct 3, 2001·Tissue Antigens·N PimtanothaiA H Johnson
Oct 19, 2001·Genes and Immunity·A RichardsonD Kwiatkowski

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Citations

Nov 26, 2003·Blood Cells, Molecules & Diseases·James C BartonErnest Beutler
Jun 12, 2004·Critical Care Medicine·Jose Garnacho-MonteroTeresa Aldabo-Pallas
Sep 29, 2011·Current Opinion in Hematology·William ArceseAlessandra Picardi
Apr 12, 2007·Pediatric Research·Shannon A RossSuresh Boppana
Nov 28, 2012·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Mu HuijunZhang Bin
Jun 15, 2007·Clinics in Dermatology·Daniel A CulverMani S Kavuru
Apr 28, 2007·Human Immunology·Gurvinder KaurN K Mehra
May 16, 2008·International Journal of Immunogenetics·S JastiV L Valluri
Feb 3, 2015·American Journal of Physical Anthropology·Eric C Shattuck, Michael P Muehlenbein
Jul 22, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Alexander DewKoen van Besien
Mar 18, 2011·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Hong-Wei JiangFu-Ren Zhang
Jan 13, 2006·Journal of the European Academy of Dermatology and Venereology : JEADV·S M B MirandaA L Filgueira

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