HLA class II antibodies in transfusion-related acute lung injury

Transfusion
Patricia M KopkoPaul V Holland

Abstract

Transfusion-related acute lung injury (TRALI) is a serious, sometimes fatal, complication of transfusion. Granulocyte and HLA class I antibodies present in blood donors have been associated with TRALI. HLA class II antibodies have recently been described in a few cases of TRALI. Donors involved in TRALI reactions reported to a blood center over an 18-month period were tested for HLA class I and II antibodies as well as granulocyte antibodies, if HLA antibodies were not identified. HLA class II antibodies were identified, in at least one donor, in 7 (64%) of 11 cases of TRALI. HLA class I antibodies were identified in combination with HLA class II antibodies in 5 of these 7 cases. HLA class I antibodies were exclusively identified in 2 cases. Granulocyte antibodies were identified in 1 case, and no antibodies were identified in another. In addition to HLA class I antibodies, HLA class II antibodies are associated with TRALI. Testing of donors for HLA class II antibodies as well as HLA class I and granulocyte antibodies is recommended as part of the investigation of suspected cases of TRALI.

References

Nov 11, 1975·Transfusion·E P ReeseP R Craddock
Mar 1, 1988·Transfusion·J C O'ConnorL B Knox
Dec 1, 1987·The American Journal of Forensic Medicine and Pathology·M B Ausley
Dec 1, 1972·British Journal of Haematology·P B KernoffF W Wright
Jul 1, 1983·The American Review of Respiratory Disease·M A PopovskyS B Moore
Apr 1, 1981·The British Journal of Surgery·N W EversonP R Bell
Feb 1, 1995·The Journal of Infectious Diseases·J Gómez-JiménezA Salgado
Apr 29, 1998·The Journal of Clinical Investigation·C C SillimanD R Ambruso
Dec 9, 1998·Digestive Surgery·W HauptW Hohenberger
May 8, 1999·British Journal of Haematology·P M Kopko, P V Holland
Mar 29, 2001·Transfusion·M A Popovsky, R D Davenport
Sep 1, 1957·Vox Sanguinis·T E BRITTINGHAM

❮ Previous
Next ❯

Citations

Apr 6, 2013·Der Anaesthesist·S TankR Kiefmann
Mar 26, 2004·Human Immunology·Robert A BrayHoward M Gebel
May 17, 2005·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·J Y Muller
Jun 1, 2005·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·J-Y Muller
May 7, 2013·Lancet·Alexander P J Vlaar, Nicole P Juffermans
Jun 9, 2004·Blood Reviews·Joanna Mary Heal, Neil Blumberg
Oct 19, 2002·Transfusion·María VarelaMiguel Lozano
May 27, 2006·The American Journal of Nursing·Maureen A Knippen
Apr 18, 2006·Critical Care Medicine·Christopher C Silliman
Apr 18, 2006·Critical Care Medicine·Brian R Curtis, Janice G McFarland
Oct 12, 2005·Current Opinion in Hematology·Kathryn E Webert, Morris A Blajchman
Jan 16, 2010·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·Patricia M Kopko
Mar 6, 2003·Vox Sanguinis·Mark A Popovsky
Jan 1, 2008·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Mark A Popovsky
Jan 15, 2011·Blood·Brian R Curtis
Feb 20, 2009·Anesthesia and Analgesia·Darrell J Triulzi
Feb 20, 2009·Anesthesia and Analgesia·Jeanne E Hendrickson, Christopher D Hillyer
Aug 16, 2006·Langenbeck's Archives of Surgery·Marco BueterMartin Fein
Jul 20, 2007·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Giuseppe Famularo, Michele Galluzzo
Nov 12, 2002·Medical and Pediatric Oncology·George BriassoulisTassos Hatzis
Mar 19, 2011·Digestive Diseases and Sciences·Ponni V Perumalswami, Thomas D Schiano
Jun 21, 2013·Expert Review of Hematology·F Bernadette West, Christopher C Silliman
Jan 26, 2012·Expert Review of Hematology·Marcella C A Müller, Nicole P Juffermans
Oct 17, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Robert S Rahimi, Jacqueline G O'Leary
Aug 28, 2012·Critical Care Nursing Clinics of North America·Alexander B Benson
Nov 25, 2005·Chest·Aryeh Shander, Mark A Popovsky
Jul 14, 2004·Chest·Mark R LooneyMichael A Matthay
Jun 12, 2012·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·A P J Vlaar
Sep 22, 2009·Transfusion Medicine Reviews·Yoke Lin Fung, Christopher C Silliman
May 19, 2009·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·P RenaudierC Caldani
Dec 6, 2008·Transfusion Medicine Reviews·Lennart E LögdbergChristopher D Hillyer
Jun 21, 2007·American Journal of Clinical Pathology·Rosa SanchezPearl Toy
May 9, 2008·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Manuel MuroMaría R Alvarez-López
Nov 27, 2007·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Ulrich J H Sachs
Jul 27, 2007·Best Practice & Research. Clinical Anaesthesiology·Pearl Toy, Clifford Lowell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.