HLA class II associations with idiopathic nephrotic syndrome in children

Tissue Antigens
M KonradK Schärer

Abstract

The occasional familial occurrence of idiopathic nephrotic syndrome (NS) points to a genetic predisposition. Reports on associations with certain HLA class II antigens support this hypothesis. In order to define the immunogenetic background of NS more precisely, HLA class II allele frequencies in 161 children with NS were studied by restriction fragment length polymorphism (RFLP) typing. The patient cohorts consisted of 87 children from Southwest-France and 74 from Southwest-Germany. The control group consisted of 118 French and 101 German unrelated individuals from the same geographical areas. HLA alleles were defined in patients with steroid-sensitive (SS) and steroid-resistant (SR) NS and in controls. RFLP typing revealed that the previously reported association between SSNS and HLA-DR7 is confined to the RFLP split 7.1 (DRB1*07) with a combined relative risk (RRcomb) of 6.2. HLA-DQB typing showed an increased frequency of the allele DQB2b (DQB1*0201) (RRcomb = 7.8). HLA-DQA typing showed an association of SSNS with DQA3 (DQA1*0201,0301,0302) (RRcomb = 4.1). The highest RR (16.5) for SSNS was found in German patients who carried the two DRB1 specificities 17.1 (DRB1*0301) and 7.1 (DRB1*07). All associations were stronger in ...Continue Reading

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Citations

Dec 31, 2004·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ashraf M BakrFatma Al-Husseni
Sep 13, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Aleksandra Krasowska-KwiecieńAnna Moczulska
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May 6, 2016·Frontiers in Pediatrics·Rahul Chanchlani, Rulan S Parekh
Jul 30, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Alana M Karp, Rasheed A Gbadegesin
Oct 29, 2014·Journal of the American Society of Nephrology : JASN·Rasheed A GbadegesinUNKNOWN Mid-West Pediatric Nephrology Consortium
Jul 18, 2018·Journal of the American Society of Nephrology : JASN·Xiaoyuan JiaUNKNOWN Research Consortium on Genetics of Childhood Idiopathic Nephrotic Syndrome in Japan
Jun 27, 2018·Frontiers in Medicine·Roberta BertelliG M Ghiggeri
Dec 21, 2018·Pediatric Research·Limor ParkerMichael Goldman
Feb 15, 2019·Frontiers in Pediatrics·Brandon M LaneRasheed A Gbadegesin
Sep 13, 2018·Nature Reviews. Nephrology·Kate J RobsonA Richard Kitching
Oct 22, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Stephanie Dufek-KamperisMallory L Downie

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