HLA class II genetic diversity in southern Tunisia and the Mediterranean area

International Journal of Immunogenetics
B Abdennaji GuenounouA Sanchez-Mazas

Abstract

North Africa is populated by many Arab- and Berber-speaking populations whose genetic history is still poorly understood. In this study, we analyse the HLA-DRB1 and DQB1 molecular diversity in three populations from the south of Tunisia--Berbers from Jerba, Berbers from Matmata and Arabs from Gabes--and we compare them to a large set of populations from the whole Mediterranean region. Among the three populations studied, the Berbers from Jerba are the most peculiar, as they diverge significantly from other North Africans while being genetically highly diversified and close to populations from the Near East. Thus, Jerba may have been a crossing point, in historical times, where colonization from the eastern Mediterranean area left significant genetic traces. By contrast, the populations from Matmata and Gabes are genetically similar to other Arab and Berber-speaking populations from different areas of the Maghrib, despite some peculiar allele and haplotype frequencies. At a larger scale, northwest Africa and southwest Europe are closely related according to these polymorphisms, while the populations from the eastern Mediterranean area are much more differentiated. The close genetic relatedness found for HLA among populations of ...Continue Reading

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Citations

Aug 5, 2010·BMC Evolutionary Biology·Mathias CurratAlicia Sanchez-Mazas
Dec 3, 2014·Comptes rendus biologies·César Fortes-LimaRosario Calderón
Jul 30, 2010·Annals of Human Biology·A HajjejS Hmida
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Mar 10, 2011·International Journal of Immunogenetics·A HajjejS Hmida
Sep 15, 2011·American Journal of Physical Anthropology·Karima Fadhlaoui-ZidDavid Comas
Jul 31, 2010·Tissue Antigens·K Fadhlaoui-ZidAlicia Sanchez-Mazas
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Nov 15, 2015·Nephrology·Aravind Selvin Kumar RamanathanBalakrishnan Karuppiah
Nov 25, 2016·Journal of Human Genetics·Abdelhafidh HajjejSlama Hmida
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Jun 5, 2019·Immunological Investigations·Monia MessoussiKarima Fadhlaoui-Zid

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