HLA-class II haplotypes and Autism Spectrum Disorders

Scientific Reports
Meriem BennabiRyad Tamouza

Abstract

Infections and autoimmunity are associated with autism spectrum disorders (ASD), with both strongly influenced by the genetic regulation of the human leukocyte antigen (HLA) system. The relationship between ASD and the HLA genetic diversity requires further investigation. Using a case control design, the distribution of HLA class II-DRB1 and DQB1 alleles, genotypes and haplotypes were investigated in ASD patients, versus healthy controls (HC). ASD patients meeting DSM-IV TR criteria and HC (474 and 350 respectively) were genotyped at medium resolution using a Luminex-based SSO technology. Comparisons of genotypes, allele frequencies associated with a haplotype analysis were performed. Results indicate: (i) the HLA-DRB1 *11-DQB1*07 haplotype was more prevalent in ASD patients, versus HC (Pc = 0.001), partially replicating previous data and possibly linking to gastro-intestinal (GI)-related pro-inflammatory processes, given that this haplotype associates with pediatric celiac disorders; (ii) the HLA-DRB1 *17-DQB1*02 haplotype was higher in HC, versus ASD patients (Pc = 0.002), indicating that this is a protective haplotype. Using the Autism Diagnostic Interview to assess clinical dimensions, higher scores on social (Pc = 0.006) a...Continue Reading

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Citations

Oct 9, 2019·Autism Research : Official Journal of the International Society for Autism Research·Ryad TamouzaChristopher Gillberg
Aug 27, 2019·Frontiers in Genetics·Yan SunJin Li
Jul 9, 2020·Neuropsychiatric Disease and Treatment·Regina SalaPaul Whiteley
Aug 6, 2020·International Journal of Molecular Sciences·Mahesh MohanKarol Sestak
Sep 28, 2018·Pediatric Neurology Briefs·Hakim Rahmoune, Nada Boutrid
Feb 13, 2021·Nutrients·Iain D CroallMarios Hadjivassiliou

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Methods Mentioned

BETA
genotyping

Software Mentioned

stats
haplo
R
HLA visual

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