HLA class II typing using oligonucleotide probes

Genetic Epidemiology
D M RobinsonG T Nepom

Abstract

A DQ beta locus-specific oligonucleotide probe is used to identify DQ beta alleles present in six insulin-dependent diabetes mellitus (IDDM) multiplex families. Results of genotyping using this technique agree with those from cDNA probes and are often clearer. Allele-specific oligonucleotide probes for the DR beta locus are used to identify subtypes (Dw4 and Dw14) of the DR4 specificity in five IDDM multiplex families. This distinction cannot be made with available cDNA probes.

References

Dec 1, 1987·Transplantation·A AmarG T Nepom
Jul 1, 1985·The Journal of Immunology : Official Journal of the American Association of Immunologists·S L HolbeckG T Nepom
Mar 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·W I WoodR M Lawn

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Citations

Nov 1, 1989·Clinical Immunology and Immunopathology·G T Nepom
Mar 1, 1993·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·M Bauernfeind, W G Wood

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