HLA-Cw6-positive patients with psoriasis show improved response to methotrexate treatment

Clinical and Experimental Dermatology
J WestJ Foerster

Abstract

It is well documented that patients with human leucocyte antigen (HLA)-Cw6+ (type 1) psoriasis have increased severity and reduced age of onset of psoriasis. However, not much is known about any differential response of this genetic subgroup to various treatments. We set out to determine if there was any genetic association of the HLA-Cw6 allele with the first-line systemic treatment commonly used in psoriasis, methotrexate. A cohort of patients from Tayside in Scotland was recruited through a novel generic consenting process (GoShare); they were extensively phenotyped and analysed for an association of their HLA-Cw6 genotype status with treatment outcomes. HLA-Cw6+ patients showed notably improved response to methotrexate (P = 0.05), and further analysis demonstrated an even greater response in a subcohort of the HLA-Cw6+ patients, who did not have concomitant psoriatic arthritis (P = 0.01). HLA-Cw6+ patients also exhibited fewer treatment-limiting adverse events. In addition to these findings, the methodology and primary clinical outcome phenotype, which we validate here, will greatly facilitate replication of the present results in independent cohorts.

References

Sep 20, 2008·Clinical and Experimental Dermatology·R B WarrenA Menter
Nov 20, 2008·The British Journal of Dermatology·R B WarrenC E M Griffiths
Dec 3, 2014·Human Immunology·Renata SokolikKatarzyna Bogunia-Kubik
Feb 8, 2016·The British Journal of Dermatology·J WestJ Foerster

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Citations

Feb 10, 2018·International Journal of Molecular Sciences·Marie-Astrid BoutetCostantino Pitzalis
Oct 27, 2017·The British Journal of Dermatology·L Chen, T-F Tsai
Aug 11, 2017·Dermatologic Therapy·Ayman Abdelmaksoud
Mar 27, 2019·International Journal of Molecular Sciences·Adriana Rendon, Knut Schäkel
Jan 19, 2021·American Journal of Clinical Dermatology·Yi-Wei Huang, Tsen-Fang Tsai
Apr 13, 2021·Frontiers in Immunology·Khalaf KridinRalf J Ludwig

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