Nov 1, 1991

HLA-DPB1 gene polymorphism and multiple sclerosis: a large case-control study in the southwest of France

Journal of Neuroimmunology
M P RothM Clanet

Abstract

The polymorphism at the HLA-DPB1 locus has been characterized in a large number of patients with multiple sclerosis (n = 112) and in healthy controls (n = 115). Both patients and controls lived in the southwest of France (in the Pyrénées Atlantiques) and had similar ethnic background. The typing procedure involved the selective amplification of the second exon of the DPB1 locus by polymerase chain reaction, followed by hybridization of the amplified DNA with 14 sequence-specific oligonucleotide probes. Individual alleles were identified by the pattern of hybridization of the different probes. The distribution of the DPB1 alleles was not significantly different in multiple sclerosis patients and controls (p = 0.11). This does not corroborate the reported association of multiple sclerosis with the primed lymphocyte typing (PLT)-defined DPw4 specificity and is not in favour of a role played by polymorphic residues of the DP molecule in susceptibility to multiple sclerosis.

Mentioned in this Paper

Exons
Nucleic Acid Hybridization Procedure
Polymerase Chain Reaction Analysis
Oligonucleotide Probes
Gene Amplification Technique
HLA-DPB1 gene
Nested Case-Control Studies
MS gene
Locus
Gene Amplification Abnormality

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