Oct 15, 1987

HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus

Nature
J A ToddH O McDevitt

Abstract

Over half of the inherited predisposition to insulin-dependent diabetes mellitus maps to the region of chromosome 6 that contains the highly polymorphic HLA class II genes which determine immune responsiveness. Analysis of DNA sequences from diabetics indicates that alleles of HLA-DQ beta determine both disease susceptibility and resistance, and that the structure of the DQ molecule, in particular residue 57 of the beta-chain, specifies the autoimmune response against the insulin-producing islet cells.

Mentioned in this Paper

Chromosomes, Human, Pair 6
Genes, MHC Class II
Haploid Cell
Disease Susceptibility
HLA-DR Antigens
Oligonucleotides
Immune-Associated Antigens
Diabetes Mellitus, Insulin-Dependent
Diabetes, Autoimmune
Alleles

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