HLA-DQ Mismatches and Rejection in Kidney Transplant Recipients

Clinical Journal of the American Society of Nephrology : CJASN
Wai H LimG Wong

Abstract

The current allocation algorithm for deceased donor kidney transplantation takes into consideration HLA mismatches at the ABDR loci but not HLA mismatches at other loci, including HLA-DQ. However, the independent effects of incompatibilities for the closely linked HLA-DQ antigens in the context of HLA-DR antigen matched and mismatched allografts are uncertain. We aimed to determine the effect of HLA-DQ mismatches on renal allograft outcomes. Using data from the Australia and New Zealand Dialysis and Transplant Registry, we examined the association between HLA-DQ mismatches and acute rejections in primary live and deceased donor kidney transplant recipients between 2004 and 2012 using adjusted Cox regression models. Of the 788 recipients followed for a median of 2.8 years (resulting in 2891 person-years), 321 (40.7%) and 467 (59.3%) received zero and one or two HLA-DQ mismatched kidneys, respectively. Compared with recipients who have received zero HLA-DQ mismatched kidneys, those who have received one or two HLA-DQ mismatched kidneys experienced greater numbers of any rejection (50 of 321 versus 117 of 467; P<0.01), late rejections (occurring >6 months post-transplant; 8 of 321 versus 27 of 467; P=0.03), and antibody-mediated r...Continue Reading

References

Apr 1, 1994·The British Journal of Surgery·I J BeckinghamM L Nicholson
Dec 24, 1996·Proceedings of the National Academy of Sciences of the United States of America·E W PetersdorfJ A Hansen
May 25, 2012·Kidney International·Jennifer M DeVosSamir J Patel
Jul 5, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·E C JollyM R Clatworthy
Sep 11, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·F GinevriF Poli
Oct 30, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C WiebeP W Nickerson
Mar 19, 2014·Transplant International : Official Journal of the European Society for Organ Transplantation·Augusto TagliamaccoArcangelo Nocera
Dec 19, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R Sapir-PichhadzeS J Kim

❮ Previous
Next ❯

Citations

Apr 2, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Nagaraju Sarabu, Donald E Hricik
Aug 9, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A NoceraF Ginevri
Jan 11, 2017·Journal of Immunology Research·Edward J Filippone, John L Farber
Apr 6, 2018·Annals of Saudi Medicine·Osama OmraniNedim Selimovic
Jul 10, 2018·Nature Reviews. Nephrology·Robert A MontgomeryAndrea A Zachary
Apr 25, 2018·Clinical Journal of the American Society of Nephrology : CJASN·Napat LeeaphornFrancesca Cardarelli
Feb 26, 2019·Transplantation·David N Rush, Ian W Gibson
Sep 25, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Samira FaroukMadhav C Menon
Dec 19, 2019·Clinical Journal of the American Society of Nephrology : CJASN·David P Foley, Deirdre Sawinski
Apr 11, 2020·HLA : Immune Response Genetics·Dianne De SantisLloyd D'Orsogna
May 14, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Neetika GargDidier A Mandelbrot
Dec 23, 2016·Frontiers in Immunology·Andrea A Zachary, Mary S Leffell
Mar 21, 2018·Frontiers in Immunology·Kirsten GeneugelijkEric Spierings
Apr 26, 2018·Journal of Immunology Research·Tilahun AlelignBeyene Petros
Dec 11, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jon Jin KimStephen D Marks
Oct 6, 2020·Inflammation and Regeneration·Keiko KogaShin Kaneko
Nov 2, 2020·Pediatric Transplantation·Nicole HaydeAdriana Colovai
Oct 17, 2020·Annals of Laboratory Medicine·Soo-Kyung KimHeung-Bum Oh
Sep 1, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Kyle R Jackson, Dorry L Segev

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.